Rabbit nth endonuclease III-like 1 Polyclonal Antibody | anti-NTHL1 antibody
Rabbit anti-human nth endonuclease III-like 1 (E. coli) polyclonal Antibody
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
Uniprot Description
NTHL1: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. Belongs to the Nth/MutY family.
Protein type: Lyase; Mitochondrial; EC 4.2.99.18; Hydrolase; DNA repair, damage
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: nucleoplasm; mitochondrion; nucleus
Molecular Function: protein binding; DNA-(apurinic or apyrimidinic site) lyase activity; metal ion binding; endonuclease activity; 4 iron, 4 sulfur cluster binding; double-stranded DNA binding; DNA N-glycosylase activity
Biological Process: base-excision repair, AP site formation; base-excision repair; depyrimidination; DNA repair; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA catabolic process, endonucleolytic
Disease: Familial Adenomatous Polyposis 3
Research Articles on NTHL1
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Product Notes
The NTHL1 nthl1 (Catalog #AAA716174) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human nth endonuclease III-like 1 (E. coli) polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's nth endonuclease III-like 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the NTHL1 nthl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "nth endonuclease III-like 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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