Rabbit anti-Human VDAC3 Polyclonal Antibody | anti-VDAC3 antibody
Rabbit anti-Human VDAC3 Polyclonal Antibody
Constituents: 50% Glycerol, 0.01M PBS, pH7.4
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
VDAC3: a protein of the eukaryotic mitochondrial porin family. Forms a voltage-dependent anion channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Two splice-variant isoforms have been described.
Protein type: Channel, misc.; Mitochondrial; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p11.2
Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; nucleus
Molecular Function: nucleotide binding; voltage-gated anion channel activity; porin activity
Biological Process: adenine transport; transmembrane transport; anion transport