Rabbit anti-Human VDAC3 Polyclonal Antibody | anti-VDAC3 antibody

VDAC3 Polyclonal Antibody

Cat. Num. AAA3010376

• Gene Names: VDAC3; VDAC-3; HD-VDAC3
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: VDAC3; Polyclonal Antibody; VDAC3 Polyclonal Antibody; HD-VDAC3; VDAC-3; anti-VDAC3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: VDAC3 polyclonal antibody detects endogenous levels of VDAC3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 283

• Applicable Applications for anti-VDAC3 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:1000-1:2000; IF: 1:50-1:200
• Immunogen: Recombinant protein of human VDAC3
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of A-431 cells, using VDAC3 antibody.)

Related Product Information for anti-VDAC3 antibody

This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 12643945
• NCBI GeneID: 7419
• UniProt Accession #: Q9Y277
• Molecular Weight: ~ 31kDa
• NCBI Official Full Name: Voltage-dependent anion-selective channel protein 3
• NCBI Official Synonym Full Names: voltage dependent anion channel 3
• NCBI Official Symbol: VDAC3
• NCBI Official Synonym Symbols: VDAC-3; HD-VDAC3
• NCBI Protein Information: voltage-dependent anion-selective channel protein 3
• UniProt Protein Name: Voltage-dependent anion-selective channel protein 3
• Protein Family: Voltage-dependent anion-selective channel protein
• UniProt Gene Name: VDAC3
• UniProt Synonym Gene Names: VDAC-3; hVDAC3
• UniProt Entry Name: VDAC3_HUMAN

NCBI Description

This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

VDAC3: a protein of the eukaryotic mitochondrial porin family. Forms a voltage-dependent anion channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Two splice-variant isoforms have been described.

Protein type: Channel, misc.; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; nucleus

Molecular Function: nucleotide binding; voltage-gated anion channel activity; porin activity

Biological Process: adenine transport; transmembrane transport; anion transport