Rabbit anti-Human, Mouse NLRP10 Polyclonal Antibody | anti-NLRP10 antibody

NLRP10 Antibody

Cat. Num. AAA7129384

• Gene Names: NLRP10; NOD8; PAN5; PYNOD; NALP10; CLR11.1
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Antigen Affinity Purification
• Synonyms: NLRP10; Polyclonal Antibody; NLRP10 Antibody; NLR family; pyrin domain containing 10; anti-NLRP10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: Liquid

• Applicable Applications for anti-NLRP10 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:2000-1:5000; WB: 1:500-1:2000
• Immunogen: Synthetic peptide of human NLRP10
• Immunogen Species: Homo sapiens (Human)
• Conjugate: Non-conjugated
• Storage Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Target Names: NLRP10
• Preparation and Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

SDS-PAGE

(Gel: 8% SDS-PAGE, Lysate: 40 ug, Lane 1-2: Mouse heart tissue, Mouse skeletal muscle tissue, Primary antibody: MBS7129384 (NLRP10 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minutes)

Product Categories/Family for anti-NLRP10 antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 28827807
• NCBI GeneID: 338322
• NCBI Accession #: NP_789791
• NCBI GenBank Nucleotide #: NM_176821.3
• UniProt Accession #: Q86W26; Q2M3C4; Q6JGT0
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 10
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 10
• NCBI Official Symbol: NLRP10
• NCBI Official Synonym Symbols: NOD8; PAN5; PYNOD; NALP10; CLR11.1
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 10; NACHT, leucine rich repeat and PYD containing 10; nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 10
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP10
• UniProt Synonym Gene Names: NALP10; NOD8; PYNOD
• UniProt Entry Name: NAL10_HUMAN

NCBI Description

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

NALP10: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Belongs to the NLRP family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: extrinsic to plasma membrane; cytoplasm

Molecular Function: ATP binding

Biological Process: positive regulation of T-helper 1 type immune response; innate immune response; defense response to Gram-negative bacterium; defense response to fungus