Rabbit anti-Human, Mouse PSMD3 Polyclonal Antibody | anti-PSMD3 antibody

PSMD3 Antibody

Cat. Num. AAA7124197

• Gene Names: PSMD3; S3; P58; RPN3; TSTA2
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purification
• Synonyms: PSMD3; Polyclonal Antibody; PSMD3 Antibody; proteasome (prosome; macropain) 26S subunit; non-ATPase; 3; anti-PSMD3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: Liquid; In Phosphate Buffered Saline, pH 7.4, 0.05% NaN3, and 40% Glycerol

• Applicable Applications for anti-PSMD3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: ELISA: 1:1000-1:5000; WB: 1:200-1:1000; IHC: 1:50-1:200
• Immunogen: Fusion protein of human PSMD3
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)-Paraffin

(The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using MBS7124197(PSMD3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200))

Immunohistochemistry (IHC)-Paraffin

(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MBS7124197(PSMD3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200))

SDS-Page

(Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Hela cells, Jurkat cells, Primary antibody: MBS7124197(PSMD3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds)

Product Categories/Family for anti-PSMD3 antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 25777612
• NCBI GeneID: 5709
• NCBI Accession #: NP_002800.2
• NCBI GenBank Nucleotide #: NM_002809.3
• UniProt Accession #: O43242; Q96EI2; Q9BQA4; B3KMW9
• Molecular Weight: 60,978 Da
• NCBI Official Full Name: 26S proteasome non-ATPase regulatory subunit 3
• NCBI Official Synonym Full Names: proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
• NCBI Official Symbol: PSMD3
• NCBI Official Synonym Symbols: S3; P58; RPN3; TSTA2
• NCBI Protein Information: 26S proteasome non-ATPase regulatory subunit 3; proteasome subunit p58; 26S proteasome regulatory subunit S3; 26S proteasome regulatory subunit RPN3; tissue specific transplantation antigen 2
• UniProt Protein Name: 26S proteasome non-ATPase regulatory subunit 3
• Protein Family: 26S proteasome non-ATPase regulatory
• UniProt Gene Name: PSMD3
• UniProt Entry Name: PSMD3_HUMAN

NCBI Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]

Uniprot Description

PSMD3: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the proteasome subunit S3 family.

Protein type: Proteasome complex; Protease

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: nucleoplasm; proteasome complex; membrane; cytoplasm; nucleus; cytosol

Molecular Function: enzyme regulator activity

Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis