Rabbit anti-Human, Mouse DOK2 Polyclonal Antibody | anti-DOK2 antibody

Phospho-DOK2 (Y345) Antibody

Cat. Num. AAA7121201

• Gene Names: DOK2; p56DOK; p56dok-2
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: DOK2; Polyclonal Antibody; Phospho-DOK2 (Y345) Antibody; Docking protein 2; Downstream of Tyrosine kinase 2; p56(dok-2); anti-DOK2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; In Phosphate Buffered Saline, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.

• Applicable Applications for anti-DOK2 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:100-1:300; ELISA: 1:20000
• Immunogen: Synthesized peptide derived from human Dok-2 around the phosphorylation site of Y345.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Product Categories/Family for anti-DOK2 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 41406050
• NCBI GeneID: 9046
• NCBI Accession #: NP_003965.2
• NCBI GenBank Nucleotide #: NM_003974.2
• UniProt Accession #: O60496; Q8N5A4
• Molecular Weight: 45,379 Da
• NCBI Official Full Name: docking protein 2
• NCBI Official Synonym Full Names: docking protein 2, 56kDa
• NCBI Official Symbol: DOK2
• NCBI Official Synonym Symbols: p56DOK; p56dok-2
• NCBI Protein Information: docking protein 2; p56(dok-2); downstream of tyrosine kinase 2
• UniProt Protein Name: Docking protein 2
• Protein Family: Docking protein
• UniProt Gene Name: DOK2
• UniProt Entry Name: DOK2_HUMAN

NCBI Description

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

Uniprot Description

DOK2: a member of the p62dok family of proteins that interact with receptor tyrosine kinases and mediate particular biological responses. Constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/Abl), a chimeric protein whose presence is associated with CML. Contains a pleckstrin homology domain at the amino terminus, 13 potential tyrosine phosphorylation sites, and six PXXP SH3 recognition motifs. Binds p120 (RasGAP) from CML cells.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cytosol

Molecular Function: receptor signaling protein activity; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding

Biological Process: cell surface receptor linked signal transduction; Ras protein signal transduction; blood coagulation; signal transduction; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway