Glucagon-Like Peptide 1 Receptor (GLP1R) Recombinant Protein | GLP1R recombinant protein

Recombinant Human Glucagon-Like Peptide 1 Receptor (GLP1R)

Cat. Num. AAA7115353

• Gene Names: GLP1R; GLP-1; GLP-1R; GLP-1-R
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Glucagon-Like Peptide 1 Receptor (GLP1R); Recombinant Human Glucagon-Like Peptide 1 Receptor (GLP1R); GLP1R recombinant protein

• Host: In Vitro E Coli Expression System
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Tris-Based Buffer, 50% Glycerol
• Sequence Positions: 24-463aa; Full Length of Mature Protein
• Sequence: RPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

• Species: Human
• Tag: N-terminal 10xHis-tagged
• Subcellular Location: Cell Membrane, Multi-Pass Membrane Protein
• Protein Families: G-protein coupled receptor 2 family
• Pathway: cAMP Signaling Pathway
• Production Note: Special Offer: The Cell Free host-expressed protein is manufactured from a stock plasmid containing the protein gene. Cell Freehost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Cell Free host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Cell Free host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.; Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for GLP1R recombinant protein

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Product Categories/Family for GLP1R recombinant protein

Neuroscience

References

"Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor." Thorens B., Porret A., Buehler L., Deng S., Morel P., Widmann C. Diabetes 42:1678-1682(1993).

NCBI and Uniprot Product Information

• NCBI GI #: 166795283
• NCBI GeneID: 2740
• NCBI Accession #: NP_002053.3
• NCBI GenBank Nucleotide #: NM_002062.5
• UniProt Accession #: P43220
• Molecular Weight: 53.6 kDa
• NCBI Official Full Name: glucagon-like peptide 1 receptor
• NCBI Official Synonym Full Names: glucagon like peptide 1 receptor
• NCBI Official Symbol: GLP1R
• NCBI Official Synonym Symbols: GLP-1; GLP-1R; GLP-1-R
• NCBI Protein Information: glucagon-like peptide 1 receptor
• UniProt Protein Name: Glucagon-like peptide 1 receptor
• Protein Family: Glucagon-like peptide 1 receptor
• UniProt Gene Name: GLP1R
• UniProt Synonym Gene Names: GLP-1 receptor; GLP-1-R; GLP-1R

NCBI Description

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Uniprot Description

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 ().