Polycystic kidney disease 2-like 1 protein (PKD2L1) Recombinant Protein | PKD2L1 recombinant protein

Recombinant Human Polycystic kidney disease 2-like 1 protein (PKD2L1) , partial

• Gene Names: PKD2L1; PCL; PKDL; PKD2L; TRPP3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Polycystic kidney disease 2-like 1 protein (PKD2L1); Recombinant Human Polycystic kidney disease 2-like 1 protein (PKD2L1); partial; PKD2L1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 776

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 359465612
• NCBI GeneID: 9033
• NCBI Accession #: NP_001240766.1
• NCBI GenBank Nucleotide #: NM_001253837.1
• UniProt Accession #: Q9P0L9; O75972; Q5W039; Q9UP35; Q9UPA2
• Molecular Weight: 88,472 Da
• NCBI Official Full Name: polycystic kidney disease 2-like 1 protein isoform 2
• NCBI Official Synonym Full Names: polycystin 2 like 1, transient receptor potential cation channel
• NCBI Official Symbol: PKD2L1
• NCBI Official Synonym Symbols: PCL; PKDL; PKD2L; TRPP3
• NCBI Protein Information: polycystic kidney disease 2-like 1 protein
• UniProt Protein Name: Polycystic kidney disease 2-like 1 protein
• Protein Family: Polycystic kidney disease 2-like 1 protein
• UniProt Gene Name: PKD2L1
• UniProt Synonym Gene Names: PKD2L; PKDL; TRPP3

NCBI Description

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.