Calcium-activated potassium channel subunit alpha-1 (KCNMA1) Recombinant Protein | KCNMA1 recombinant protein

Recombinant Dog Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Calcium-activated potassium channel subunit alpha-1 (KCNMA1); Recombinant Dog Calcium-activated potassium channel subunit alpha-1 (KCNMA1); partial; KCNMA1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,159

• Species: Canis familiaris (Dog) (Canis lupus familiaris)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 926234468
• NCBI GeneID: 403984
• NCBI Accession #: NP_001003300.2
• NCBI GenBank Nucleotide #: NP_001003300.2
• UniProt Accession #: Q28265
• Molecular Weight: 130,296 Da
• NCBI Official Full Name: calcium-activated potassium channel subunit alpha-1
• UniProt Protein Name: Calcium-activated potassium channel subunit alpha-1
• Protein Family: Calcium-activated potassium channel
• UniProt Gene Name: KCNMA1
• UniProt Synonym Gene Names: KCNMA; MaxiK; Slo homolog

Uniprot Description

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. It is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca2+, caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) ().