Rabbit anti-Human CDC42EP3 Polyclonal Antibody | anti-CDC42EP3 antibody

CDC42EP3 Antibody

Cat. Num. AAA7053349

• Gene Names: CDC42EP3; UB1; CEP3; BORG2
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G purified
• Synonyms: CDC42EP3; Polyclonal Antibody; CDC42EP3 Antibody; Cdc42 effector protein 3; Binder of Rho GTPases 2; MSE55-related Cdc42-binding protein; BORG2; CEP3; anti-CDC42EP3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 254

• Applicable Applications for anti-CDC42EP3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:20-1:200
• Immunogen: Recombinant Human Cdc42 effector protein 3 protein (1-226AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue using MBS7053349 at dilution of 1:100)

Related Product Information for anti-CDC42EP3 antibody

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.

NCBI and Uniprot Product Information

• NCBI GI #: 395627662
• NCBI GeneID: 10602
• NCBI Accession #: NP_001257365.1
• NCBI GenBank Nucleotide #: NM_001270436.1
• UniProt Accession #: Q9UKI2; O95353; Q9UQJ0; B2R8S0
• Molecular Weight: 27,678 Da
• NCBI Official Full Name: cdc42 effector protein 3
• NCBI Official Synonym Full Names: CDC42 effector protein 3
• NCBI Official Symbol: CDC42EP3
• NCBI Official Synonym Symbols: UB1; CEP3; BORG2
• NCBI Protein Information: cdc42 effector protein 3
• UniProt Protein Name: Cdc42 effector protein 3
• Protein Family: Cdc42 effector protein
• UniProt Gene Name: CDC42EP3
• UniProt Synonym Gene Names: BORG2; CEP3

NCBI Description

This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Description

CDC42EP3: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Belongs to the BORG/CEP family.

Protein type: G protein regulator, misc.

Chromosomal Location of Human Ortholog: 2p22.2

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; plasma membrane

Molecular Function: cytoskeletal regulatory protein binding; GTP-Rho binding; GTPase activator activity

Biological Process: positive regulation of actin filament polymerization; positive regulation of pseudopodium formation; regulation of cell shape; Rho protein signal transduction; signal transduction