Rabbit anti-Human NOS1AP Polyclonal Antibody | anti-NOS1AP antibody

NOS1AP Antibody

Cat. Num. AAA7052189

• Gene Names: NOS1AP; CAPON; 6330408P19Rik
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: NOS1AP; Polyclonal Antibody; NOS1AP Antibody; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Nitric oxide synthase 1 adaptor protein; CAPON; KIAA0464; anti-NOS1AP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 211

• Applicable Applications for anti-NOS1AP antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:20-1:200; IF: 1:50-1:200
• Immunogen: Recombinant Human Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (176-288AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver tissue using MBS7052189 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue using MBS7052189 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunofluorescent analysis of HepG2 cells using MBS7052189 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-NOS1AP antibody

Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 205277334
• NCBI GeneID: 9722
• NCBI Accession #: NP_001119532.2
• NCBI GenBank Nucleotide #: NM_001126060.1
• UniProt Accession #: O75052; O43564; Q3T551; Q5VU95; B7ZLF5
• Molecular Weight: 55,569 Da
• NCBI Official Full Name: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 2
• NCBI Official Synonym Full Names: nitric oxide synthase 1 adaptor protein
• NCBI Official Symbol: NOS1AP
• NCBI Official Synonym Symbols: CAPON; 6330408P19Rik
• NCBI Protein Information: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• UniProt Protein Name: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• Protein Family: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• UniProt Gene Name: NOS1AP
• UniProt Synonym Gene Names: CAPON; KIAA0464

NCBI Description

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

Uniprot Description

NOS1AP: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: caveola; cytosol; mitochondrion; nuclear membrane; nucleus; perinuclear region of cytoplasm; sarcolemma; sarcoplasmic reticulum membrane; T-tubule; Z disc

Molecular Function: nitric-oxide synthase binding; protein binding

Biological Process: chemical signal regulation of heart rate; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity

Disease: Qt Interval, Variation In