Rabbit anti-Human MR1 Polyclonal Antibody | anti-MR1 antibody

MR1 Antibody

Cat. Num. AAA7046521

• Gene Names: MR1; HLALS
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: MR1; Polyclonal Antibody; MR1 Antibody; Major histocompatibility complex class I-related gene protein; MHC class I-related gene protein; Class I histocompatibility antigen-like protein; anti-MR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 296

• Applicable Applications for anti-MR1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human Major histocompatibility complex class I-related gene protein (20-260AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-292077
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7046521 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human endometrial cancer using MBS7046521 at dilution 1:100)

Related Product Information for anti-MR1 antibody

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

NCBI and Uniprot Product Information

• NCBI GI #: 303324539
• NCBI GeneID: 3140
• NCBI Accession #: NP_001181928.1
• NCBI GenBank Nucleotide #: NM_001194999.1
• UniProt Accession #: Q95460; O97985; O97986; Q53GM1; Q95HB8; Q9MY23; Q9NPL2; Q9TQB3; Q9TQB9; Q9TQK3; A8K2V9; B4E3B1
• Molecular Weight: 25,190 Da
• NCBI Official Full Name: major histocompatibility complex class I-related gene protein isoform 2
• NCBI Official Synonym Full Names: major histocompatibility complex, class I-related
• NCBI Official Symbol: MR1
• NCBI Official Synonym Symbols: HLALS
• NCBI Protein Information: major histocompatibility complex class I-related gene protein
• UniProt Protein Name: Major histocompatibility complex class I-related gene protein
• Protein Family: Major histocompatibility complex class I-related gene protein
• UniProt Gene Name: MR1
• UniProt Synonym Gene Names: MHC class I-related gene protein
• UniProt Entry Name: HMR1_HUMAN

NCBI Description

MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]

Uniprot Description

MR1: Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. Belongs to the MHC class I family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25.3

Cellular Component: endoplasmic reticulum; plasma membrane

Molecular Function: antigen binding; MHC class I receptor activity; protein binding

Biological Process: antigen processing and presentation; immune response