Rabbit anti-Human JMJD1C Polyclonal Antibody | anti-JMJD1C antibody

JMJD1C Antibody, HRP conjugated

Cat. Num. AAA7045870

• Gene Names: JMJD1C; TRIP8; TRIP-8
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G purified
• Synonyms: JMJD1C; Polyclonal Antibody; JMJD1C Antibody; HRP conjugated; Probable JmjC domain-containing histone demethylation protein 2C; Jumonji domain-containing protein 1C; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8; JHDM2C; KIAA1380; TRIP8; anti-JMJD1C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 2358

• Applicable Applications for anti-JMJD1C antibody: ELISA (EIA)
• Species: Human
• Immunogen: Recombinant human Probable JmjC domain-containing histone demethylation protein 2C protein
• Conjugate: HRP
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-83420 / sc-83421
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-JMJD1C antibody

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 545479072
• NCBI GeneID: 221037
• NCBI Accession #: NP_001269877.1
• NCBI GenBank Nucleotide #: NM_001282948.1
• UniProt Accession #: Q15652; Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7; A0T124
• Molecular Weight: 263,157 Da
• NCBI Official Full Name: probable JmjC domain-containing histone demethylation protein 2C isoform c
• NCBI Official Synonym Full Names: jumonji domain containing 1C
• NCBI Official Symbol: JMJD1C
• NCBI Official Synonym Symbols: TRIP8; TRIP-8
• NCBI Protein Information: probable JmjC domain-containing histone demethylation protein 2C
• UniProt Protein Name: Probable JmjC domain-containing histone demethylation protein 2C
• Protein Family: Probable JmjC domain-containing histone demethylation protein
• UniProt Gene Name: JMJD1C
• UniProt Synonym Gene Names: JHDM2C; KIAA1380; TRIP8; TR-interacting protein 8; TRIP-8
• UniProt Entry Name: JHD2C_HUMAN

NCBI Description

The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Description

TRIP8: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Belongs to the JHDM2 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Demethylase; Oxidoreductase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: nucleoplasm

Molecular Function: histone demethylase activity (H3-K9 specific); protein binding; thyroid hormone receptor binding

Biological Process: blood coagulation; regulation of transcription, DNA-dependent