VAMP7 antibody pair

VAMP7 Antibody Pair

Cat. Num. AAA7041798

• Gene Names: VAMP7; SYBL1; TIVAMP; VAMP-7; TI-VAMP
• Reactivity: Human, Bovine, Horse, Pig, Goat
• Applications: ELISA
• Synonyms: VAMP7; Polyclonal Antibody Pair; VAMP7 Antibody Pair; Vesicle-associated membrane protein 7; Synaptobrevin-like protein 1; Tetanus-insensitive VAMP; VAMP7 antibody pair

• Host: Capture: Rabbit; Detection: Rabbit
• Reactivity: Human, Bovine, Horse, Pig, Goat
• Clonality: Polyclonal
• Isotype: Capture: IgG; Detection: IgG
• Form/Format: Liquid
• Concentration: The concentrations and volumes of the antibodies may vary and be lot specific. Details will be on the vial labels. (varies by lot)
• Sequence Length: 179

• Applicable Applications for VAMP7 antibody pair: Sandwich ELISA (EIA)
• Application Notes: We recommend using the capture antibody at a concentration of 0.5ug/ml and the detection antibody at a concentration of 0.2ug/ml.
• Immunogen Species: Human
• Conjugation: Capture: Non-conjugated; Detection: Biotin conjugated
• Recommended Standard: OVCAR-4 cell; PC-3 cell; (Standards are recommendations only. Compatibility of the standards in the user developed application needs to be established and confirmed by the researcher.
• Storage Buffer: Capture: 50% Glycerol, 0.01M PBS, PH 7.4; Detection: 50% Glycerol, 0.01M PBS, PH 7.4
• Other Note: Immunogen information is company proprietary information. Antibodies are sold as a pair and not available separately.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze/thaw cycles. When stored properly, products should be stable for at least 5 months.

NCBI and Uniprot Product Information

• NCBI GI #: 223468574
• NCBI GeneID: 6845
• NCBI Accession #: NP_001138621.1
• NCBI GenBank Nucleotide #: NM_001145149.2
• Molecular Weight: 20,121 Da
• NCBI Official Full Name: vesicle-associated membrane protein 7 isoform 2
• NCBI Official Synonym Full Names: vesicle associated membrane protein 7
• NCBI Official Symbol: VAMP7
• NCBI Official Synonym Symbols: SYBL1; TIVAMP; VAMP-7; TI-VAMP
• NCBI Protein Information: vesicle-associated membrane protein 7
• UniProt Protein Name: Vesicle-associated membrane protein 7
• Protein Family: Vesicle-associated membrane protein
• UniProt Gene Name: VAMP7
• UniProt Synonym Gene Names: SYBL1; VAMP-7; Ti-VAMP
• UniProt Entry Name: VAMP7_HUMAN

NCBI Description

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Uniprot Description

VAMP7: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28 and Yq12

Cellular Component: apical part of cell; cell junction; cell surface; cytoplasm; endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle; lamellipodium; late endosome membrane; lysosomal membrane; membrane; neuron projection; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; pseudopodium; secretory granule; secretory granule membrane; SNARE complex; synapse; trans-Golgi network

Molecular Function: protein binding; SNAP receptor activity; SNARE binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis; endocytosis; endosome to lysosome transport; eosinophil degranulation; ER to Golgi vesicle-mediated transport; Golgi to plasma membrane protein transport; natural killer cell degranulation; neutrophil degranulation; phagocytosis, engulfment; positive regulation of dendrite morphogenesis; post-Golgi vesicle-mediated transport; triacylglycerol transport; vesicle fusion; vesicle fusion with Golgi apparatus; vesicle transport along microtubule; vesicle-mediated transport