Thyrotropin receptor (Tshr) Recombinant Protein | Tshr recombinant protein
Recombinant Rat Thyrotropin receptor (Tshr)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
acts as a G-protein coupled receptor for thyroid-stimulating hormone; induces increased cAMP levels [RGD, Feb 2006]
Uniprot Description
TSHR: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). Defects in TSHR are found in patients affected by hyperthyroidism with different etiologies. Somatic, constitutively activating TSHR mutations and/or constitutively activating G(s)alpha mutations have been identified in toxic thyroid nodules (TTNs) that are the predominant cause of hyperthyroidism in iodine deficient areas. These mutations lead to TSH independent activation of the cAMP cascade resulting in thyroid growth and hormone production. TSHR mutations are found in autonomously functioning thyroid nodules (AFTN), toxic multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplasms characterized by TSH- independent autonomous growth, hypersecretion of thyroid hormones, and TSH suppression. Defects in TSHR are also a cause of thyroid neoplasms (papillary and follicular cancers). Autoantibodies against TSHR are directly responsible for the pathogenesis and hyperthyroidism of Graves disease. Antibody interaction with TSHR results in an uncontrolled receptor stimulation. Defects in TSHR are the cause of congenital hypothyroidism non-goitrous type 1 (CHNG1); also known as congenital hypothyroidism due to TSH resistance. CHNG1 is a non-autoimmune condition characterized by resistance to thyroid- stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG1 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland. Defects in TSHR are the cause of familial gestational hyperthyroidism (HTFG). HTFG is a condition characterized by abnormally high levels of serum thyroid hormones occurring during early pregnancy. Defects in TSHR are the cause of hyperthyroidism non- autoimmune (HTNA). It is a condition characterized by abnormally high levels of serum thyroid hormones, thyroid hyperplasia, goiter and lack of anti-thyroid antibodies. Typical features of Graves disease such as exophthalmia, myxedema, antibodies anti-TSH receptor and lymphocytic infiltration of the thyroid gland are absent. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral
Cellular Component: integral to plasma membrane; lipid raft; plasma membrane; receptor complex
Molecular Function: peptide receptor activity, G-protein coupled; thyroid-stimulating hormone receptor activity
Biological Process: adenylate cyclase activation; adult locomotory behavior; B cell differentiation; G-protein signaling, adenylate cyclase activating pathway; hormone-mediated signaling; inner ear receptor cell development; inner ear receptor stereocilium organization and biogenesis; nervous system development; positive regulation of cell proliferation; positive regulation of multicellular organism growth; regulation of locomotion
Research Articles on Tshr
Similar Products
Product Notes
The Tshr tshr (Catalog #AAA7032235) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 22-764aa; Full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Tshr tshr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: RGCTSPPCEC HQEDDFRVTC KELHQIPSLP PSTQTLKLIE THLKTIPSLA FSSLPNISRI YLSIDATLQR LEPHSFYNLS KMTHIEIRNT RSLTYIDPDA LTELPLLKFL GIFNTGLRIF PDLTKIYSTD VFFILEITDN PYMTSVPENA FQGLCNETLT LKLYNNGFTS IQGHAFNGTK LDAVYLNKNK YLTAIDKDAF GGVYSGPTLL DVSSTSVTAL PSKGLEHLKE LIAKNTWTLK KLPLSLSFLH LTRADLSYPS HCCAFKNQKK IRGILESLMC NESSIRNLRQ RKSVNVMRGP VYQEYEEGLG DNHVGYKQNS KFQEGPSNSH YYVFFEEQED EIIGFGQELK NPQEETLQAF DSHYDYTVCG DNEDMVCTPK SDEFNPCEDI MGYKFLRIVV WFVSPMALLG NVFVLFVLLT SHYKLTVPRF LMCNLAFADF CMGVYLLLIA SVDLYTHTEY YNHAIDWQTG PGCNTAGFFT VFASELSVYT LTVITLERWY AITFAMRLDR KIRLRHAYTI MAGGWVSCFL LALLPMVGIS SYAKVSICLP MDTDTPLALA YIALVLLLNV VAFVIVCSCY VKIYITVRNP QYNPRDKDTK IAKRMAVLIF TDFMCMAPIS FYALSALMNK PLITVTNSGV LLVLFYPLNS CANPFLYAIF TKAFQRDVFI LLSKFGLCKH QAQAYQAQRV CPNNNTGIQI QKIPQDTRQS LPNVQDTYEP LGSSHLTPKL QGRISEEYTQ TAL. It is sometimes possible for the material contained within the vial of "Thyrotropin receptor (Tshr), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
