E3 ubiquitin-protein ligase TRIM13 (Trim13) Recombinant Protein | Trim13 recombinant protein
Recombinant Mouse E3 ubiquitin-protein ligase TRIM13 (Trim13)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
TRIM13: E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; EC 6.3.2.-; Ligase; Ubiquitin ligase; Tumor suppressor; Membrane protein, integral
Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; intracellular; membrane
Molecular Function: coenzyme F420-0 gamma-glutamyl ligase activity; coenzyme F420-2 alpha-glutamyl ligase activity; ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; signal transducer activity; ubiquitin-protein ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; zinc ion binding
Biological Process: activation of NF-kappaB transcription factor; ER-associated protein catabolic process; innate immune response; negative regulation of viral transcription; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macroautophagy; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; signal transduction
Research Articles on Trim13
Similar Products
Product Notes
The Trim13 trim13 (Catalog #AAA7032178) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-407aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Trim13 trim13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGLLEG NVRNSLWRPS PFKCPTCRKE TSATGVNSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCVTDM QLICGICATR GEHTKHVFSS IEDAYAREKN AFESLFQSFE TWRRGDALSR LDTLETNKRK ALQLLTKDSD KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQTYDPEIN KINTILQEQR MAFNIAEAFK DVSEPIIFLQ QMQEFREKIK VIKETPLPHS NLPTSPLMKN FDTSQWGDIK LVDVDKLSLP QDTGVFTSKI PWYPYLLLMM VVLLGLLIFF GPTVFLEWSP LDELATWKDY LSSFNSYLTK SADFIEQSVF YWEQMTDGFF IFGERVKNVS LVALNNVAEF ICKYKLL. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase TRIM13 (Trim13), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
