3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2) Recombinant Protein | Hsd3b2 recombinant protein
Recombinant Mouse 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
HSD3B2: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified.
Protein type: Membrane protein, integral; Lipid Metabolism - C21-steroid hormone; Oxidoreductase; Isomerase; Mitochondrial; Lipid Metabolism - androgen and estrogen; Endoplasmic reticulum; EC 1.1.1.145; EC 5.3.3.1
Cellular Component: endoplasmic reticulum; integral to membrane; membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion
Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity; catalytic activity; isomerase activity; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; steroid delta-isomerase activity
Biological Process: metabolic process; steroid biosynthetic process
Research Articles on Hsd3b2
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Product Notes
The Hsd3b2 hsd3b2 (Catalog #AAA7016799) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-373aa; Full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Hsd3b2 hsd3b2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: PGWSCLVTGA GGFLGQRIIQ LLVQEEDLEE IRVLDKVFRP ETRKEFFNLE TSIKVTVLEG DILDTQYLRR ACQGISVVIH TAAIIDVTGV IPRQTILDVN LKGTQNLLEA CIQASVPAFI FSSSVDVAGP NSYKEIVLNG HEEECHESTW SDPYPYSKKM AEKAVLAANG SMLKNGGTLQ TCALRPMCIY GERSPLISNI IIMALKHKGI LRSFGKFNTA NPVYVGNVAW AHILAARGLR DPKKSPNIQG EFYYISDDTP HQSFDDISYT LSKEWGFCLD SSWSLPVPLL YWLAFLLETV SFLLSPIYRY IPPFNRHLVT LSGSTFTFSY KKAQRDLGYE PLVSWEEAKQ KTSEWIGTLV EQHRETLDTK SQ. It is sometimes possible for the material contained within the vial of "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Hsd3b2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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