Corticotropin-releasing factor receptor 2 (CRHR2) Recombinant Protein | CRHR2 recombinant protein
Recombinant Human Corticotropin-releasing factor receptor 2 (CRHR2)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
Uniprot Description
CRHR2: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 2
Chromosomal Location of Human Ortholog: 7p14.3
Cellular Component: dendrite; Golgi apparatus; integral to plasma membrane; nerve terminal; perikaryon; plasma membrane; rough endoplasmic reticulum
Molecular Function: corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone receptor activity; peptide hormone binding; protein binding
Biological Process: actin filament organization; activation of NF-kappaB transcription factor; catecholamine biosynthetic process; cell surface receptor linked signal transduction; cerebellum development; epithelial cell differentiation; G-protein signaling, coupled to cAMP nucleotide second messenger; hormone-mediated signaling; hypothalamus development; negative regulation of cAMP biosynthetic process; negative regulation of epinephrine secretion; negative regulation of follicle-stimulating hormone secretion; negative regulation of luteinizing hormone secretion; positive regulation of blood pressure; positive regulation of cAMP biosynthetic process; positive regulation of heart rate; positive regulation of interleukin-6 production; positive regulation of serotonin secretion; positive regulation of stress-activated MAPK cascade; protein kinase C activation; sensory perception of pain; skeletal muscle growth
Research Articles on CRHR2
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Product Notes
The CRHR2 crhr2 (Catalog #AAA7013051) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 18-411aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the CRHR2 crhr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: LAEELLLDGW GPPLDPEGPY SYCNTTLDQI GTCWPRSAAG ALVERPCPEY FNGVKYNTTR NAYRECLENG TWASKINYSQ CEPILDDKQR KYDLHYRIAL VVNYLGHCVS VAALVAAFLL FLALRSIRCL RNVIHWNLIT TFILRNVMWF LLQLVDHEVH ESNEVWCRCI TTIFNYFVVT NFFWMFVEGC YLHTAIVMTY STERLRKCLF LFIGWCIPFP IIVAWAIGKL YYENEQCWFG KEPGDLVDYI YQGPIILVLL INFVFLFNIV RILMTKLRAS TTSETIQYRK AVKATLVLLP LLGITYMLFF VNPGEDDLSQ IMFIYFNSFL QSFQGFFVSV FYCFFNGEVR SAVRKRWHRW QDHHSLRVPM ARAMSIPTSP TRISFHSIKQ TAAV. It is sometimes possible for the material contained within the vial of "Corticotropin-releasing factor receptor 2 (CRHR2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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