Cytochrome c oxidase assembly protein COX15 homolog (Cox15) Recombinant Protein | Cox15 recombinant protein
Recombinant Mouse Cytochrome c oxidase assembly protein COX15 homolog (Cox15)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
COX15: May be involved in the biosynthesis of heme A. Defects in COX15 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Defects in COX15 are a cause of Leigh syndrome (LS). An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. Belongs to the COX15/CtaA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Mitochondrial
Cellular Component: integral to membrane; membrane; mitochondrial inner membrane; mitochondrion
Molecular Function: cytochrome-c oxidase activity; oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor; oxidoreductase activity, acting on the CH-CH group of donors
Biological Process: heme a biosynthetic process; respiratory chain complex IV assembly
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Product Notes
The Cox15 cox15 (Catalog #AAA7012390) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-413aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Cox15 cox15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MQRLLLPSLR ALTGSRNVGL LVPRVASRTQ CGSSCGSQRP LRPGQYSTIT EVALQSGKGT VSLPSRAAER AVGRWLLVCS GTVAGAVILG GVTRLTESGL SMVDWHLIKE MKPPTSQEEW EAEFQKYQQF PEFKILNHDM TLAEFKFIWY MEYSHRMWGR AVGLAYILPA AYFWRKGWLN RGMKGRVLAL CGLVCFQGLL GWYMVKSGLE EKPESYDIPR VSQYRLAAHL GSALVLYCAS LWTSLSLLLP QHKLPETRQL LWLRRFAGGT AGLVFLTALS GAFVAGLDAG LVYNSFPKMG ESWIPEDLLT FSPVLKNVFE NPTMVQFDHR LLGVTSVTAI TVLYFLSRRI PLPRRTKMAA VTLLALAYAQ VALGISTLLM YVPTPLAATH QSGSLALLSG ALWLMNELRR VPK. It is sometimes possible for the material contained within the vial of "Cytochrome c oxidase assembly protein COX15 homolog (Cox15), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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