NCBI Description
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Uniprot Description
ARL6IP5: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic. Belongs to the PRA1 family.
Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Membrane protein, integral; Cytoskeletal
Chromosomal Location of Human Ortholog: 3p14
Cellular Component: cytoskeleton; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; plasma membrane
Molecular Function: protein binding
Biological Process: induction of apoptosis by oxidative stress; L-glutamate transport; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of stress-activated MAPK cascade
Product Notes
The ARL6IP5 arl6ip5 (Catalog #
AAA7002974) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ARL6IP5 Antibody; HRP conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ARL6IP5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the ARL6IP5 arl6ip5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"ARL6IP5, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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