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Testing Data

Epigen Active Protein | EPGN active protein

Human Epigen

Reactivity
Species Reactivity: Human
Cross Reactivity: Mouse
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
Epigen; Human Epigen; Recombinant Human Epigen; EPGN active protein
Ordering
For Research Use Only!
Host
E Coli
Reactivity
Species Reactivity: Human
Cross Reactivity: Mouse
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
AVTVTPPIT AQQADNIEG PIALKFSHL CLEDHNSYC INGACAFHH ELEKAICRC FTGYTGERC EHLTLTSYA
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED50 for this effect is 150-300 ng/ml.
Preparation and Storage
At -20 degree C

Testing Data

Testing Data
Related Product Information for EPGN active protein
Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, heart and in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant human Epigen is a 7.9kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF homologous portion of the Epigen precursor.
Product Categories/Family for EPGN active protein

NCBI and Uniprot Product Information

UniProt Accession #
Molecular Weight
8,149 Da
UniProt Protein Name
Epigen
Protein Family
UniProt Gene Name
EPGN
UniProt Synonym Gene Names
EPG
UniProt Entry Name
EPGN_HUMAN

Uniprot Description

Epigen: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function: growth factor activity; epidermal growth factor receptor binding

Biological Process: positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of epidermal growth factor receptor activity; activation of MAPK activity; positive regulation of cell proliferation; MAPKKK cascade; angiogenesis; positive regulation of epithelial cell proliferation

Similar Products

Product Notes

The Epigen epgn (Catalog #AAA695963) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Epigen reacts with Species Reactivity: Human Cross Reactivity: Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: AVTVTPPIT AQQADNIEG PIALKFSHL CLEDHNSYC INGACAFHH ELEKAICRC FTGYTGERC EHLTLTSYA. It is sometimes possible for the material contained within the vial of "Epigen, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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