R-Spondin-1 Active Protein | RSPO1 active protein
Mouse R-Spondin-1
NCBI and Uniprot Product Information
Uniprot Description
R-spondin-1: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Defects in RSPO1 are the cause of palmoplantar keratoderma with squamous cell carcinoma of skin and sex reversal (PKKSCC). This recessive syndrome is characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Cell development/differentiation; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4|4 D2.2
Cellular Component: extracellular space; nucleus
Molecular Function: G-protein-coupled receptor binding; heparin binding; protein binding; receptor binding
Biological Process: male meiosis; positive regulation of protein amino acid phosphorylation; positive regulation of Wnt receptor signaling pathway; regulation of gene expression; regulation of receptor internalization; Wnt receptor signaling pathway through beta-catenin
Research Articles on RSPO1
Similar Products
Product Notes
The RSPO1 rspo1 (Catalog #AAA692477) is an Active Protein produced from CHO cells and is intended for research purposes only. The product is available for immediate purchase. The Mouse R-Spondin-1 reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLER NDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF C TKCQEGLYL HKGRCYPACP EGSTAANSTM. It is sometimes possible for the material contained within the vial of "R-Spondin-1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
