IL-36RA active protein
Human IL-36RA
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
Subcellular location: Secreted.
Tissue specificity: Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Induction: By phorbol ester (PMA) and bacterial lipopolysaccharides (LPS) treatment in macrophage cell line.
Involvement in disease: Psoriasis generalized pustular (PSORP) [MIM:614204]: A life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Ref.14 Ref.15
Sequence similarities: Belongs to the IL-1 family.
Research Articles on IL-36RA
Similar Products
Product Notes
The IL-36RA il36rn (Catalog #AAA692101) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IL-36RA reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPN RALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG A KESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPE DPA WDAPITDFYF QQCD. It is sometimes possible for the material contained within the vial of "IL-36RA, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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