MIP-5 (CCL15) active protein
Human MIP-5 (CCL15)
NCBI and Uniprot Product Information
NCBI Description
This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]
Uniprot Description
Function: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. Ref.11
Subunit structure: Monomer. Ref.12
Subcellular location: Secreted.
Tissue specificity: Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients. Ref.10 Ref.11
Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
Research Articles on MIP-5 (CCL15)
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Product Notes
The MIP-5 (CCL15) ccl15 (Catalog #AAA692083) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human MIP-5 (CCL15) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: QFTNDAETEL MMSKLPLENP VVLNSFHFAA DCCTSYISQS IPCSLM KSYF ETSSECSKPG VIFLTKKGRQ VCAKPSGPGV QDCMKKLKPY S I. It is sometimes possible for the material contained within the vial of "MIP-5 (CCL15), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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