IL-10 active protein
Mouse IL-10
Gene Names
Il10; CSIF; Il-10
Reactivity
Mouse
Purity
> 98% (SDS-PAGE; HPLC)
Synonyms
IL-10; Mouse IL-10; Recombinant Murine IL-10; IL-10 active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% (SDS-PAGE; HPLC)
Form/Format
Lyophilized
Sequence
MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDN ILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE H LNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGV YKA MNEFDIFINC IEAYMMIKMK S
Sequence Length
178
Endotoxin Level
< 0.1 ng/ug of IL-10
Biological Activity
The biologically activity was measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells. The ED50 was found to be < 2 ng/ml (> 5 x 105 units/mg).
Related Product Information for IL-10 active protein
Interleukin 10 (IL-10), initially designated cytokine synthesis inhibitory factor (CSIF), was originally identified as a product of mouse T helper (Th) 2 clones that inhibited cytokine production by Th1 clones. The human ortholog of mouse IL-10 was subsequently cloned by cross-hybridization. Human and mouse IL-10 are 81% identical at the nucleotide and amino acid level. IL-10 is the prototypic member of the IL-10 cytokine family, including IL-10, IL-19, IL-20, IL-22 (IL-TIF), IL-24 and IL-26. A number of viruses, including Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV), also encode viral members of the IL-10 family. Human IL-10 has cross-species actvity and is active on mouse cells. Mouse IL-10 is species-specific and does not act on human cells.
Product Categories/Family for IL-10 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18.7 kDa
NCBI Official Full Name
interleukin-10
NCBI Official Synonym Full Names
interleukin 10
NCBI Official Symbol
Il10
NCBI Official Synonym Symbols
CSIF; Il-10
NCBI Protein Information
interleukin-10; cytokine synthesis inhibitory factor
UniProt Protein Name
Interleukin-10
UniProt Gene Name
Il10
UniProt Synonym Gene Names
Il-10; IL-10; CSIF
UniProt Entry Name
IL10_MOUSE
Uniprot Description
Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
Subunit structure: Homodimer
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the IL-10 family.
Research Articles on IL-10
Similar Products
Product Notes
The IL-10 il10 (Catalog #AAA691868) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse IL-10 reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDN ILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE H LNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGV YKA MNEFDIFINC IEAYMMIKMK S. It is sometimes possible for the material contained within the vial of "IL-10, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
