Endocan/ESM-1 Recombinant Protein | ESM-1 recombinant protein

Mouse Endocan/ESM-1

Cat. Num. AAA691809

• Gene Names: Esm1; ESM-1; AV004503; 0610042H23Rik
• Reactivity: Mouse
• Purity: >95% by SDS-PAGE and Silver staining
• Synonyms: Endocan/ESM-1; Mouse Endocan/ESM-1; Recombinant Mouse Endocan/ESM-1; Endothelial cell-specific molecule-1; endocan; ESM-1 recombinant protein

• Host: Insect Cells
• Reactivity: Mouse
• Purity/Purification: >95% by SDS-PAGE and Silver staining
• Form/Format: Lyophilized
• Sequence: N-Terminal Sequence: WSAKYAVD
• Sequence Length: 173

• N Terminal Sequence: WSAKYAVD
• Buffer: Water
• Preparation and Storage: The lyophilized mouse Endocan/ESM-1, though stable at room temperature, is best stored desiccated below 0 degree C.

Testing Data

Related Product Information for ESM-1 recombinant protein

Endocan, also known as endothelial cell-specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is up-regulated by TNFalpha, IL1beta or lipopolysaccharide and down-regulated by IFNgamma. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM1 and reducing LFA1mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing Endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.

Product Categories/Family for ESM-1 recombinant protein

Cytokines & Growth Factors

References

Lassalle P et al, J Biol Chem 271:20458, 1996 2. Bechard D et al, J Vasc Res 37:417, 2000 3. Wellner M et al, Horm Metab Res 35:217, 2003 4. Bechard D et al, J Biol Chem 276:48341, 2001 5. Bechard D et al, J Immunol 167:3099, 2001 6. Scherpereel A et al, Cancer Res 63:6084, 2003

NCBI and Uniprot Product Information

• NCBI GI #: 14196342
• NCBI GeneID: 71690
• NCBI Accession #: NP_076101.1
• NCBI GenBank Nucleotide #: NM_023612.3
• UniProt Accession #: Q9QYY7
• Molecular Weight: 20,043 Da
• NCBI Official Full Name: endothelial cell-specific molecule 1
• NCBI Official Synonym Full Names: endothelial cell-specific molecule 1
• NCBI Official Symbol: Esm1
• NCBI Official Synonym Symbols: ESM-1; AV004503; 0610042H23Rik
• NCBI Protein Information: endothelial cell-specific molecule 1
• UniProt Protein Name: Endothelial cell-specific molecule 1
• UniProt Gene Name: Esm1
• UniProt Synonym Gene Names: ESM-1
• UniProt Entry Name: ESM1_MOUSE

Uniprot Description

Function: Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions

By similarity.

Subcellular location: Secreted

By similarity.

Post-translational modification: O-glycosylated; contains chondroitin sulfate and dermatan sulfate

By similarity.

Sequence similarities: Contains 1 IGFBP N-terminal domain.