MIP-3 (CCL23) active protein

Human MIP-3 (CCL23)

Cat. Num. AAA691802

• Gene Names: CCL23; CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8
• Reactivity: Human
• Purity: 99 % (SDS-PAGE, HPLC)
• Synonyms: MIP-3 (CCL23); Human MIP-3 (CCL23); Recombinant Human MIP-3; MIP-3 (CCL23) active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: 99 % (SDS-PAGE, HPLC)
• Form/Format: Lyophilized
• Sequence: RVT kDaETEF MMSKLPLENP VLLDRFHATS ADCCISYTPR SIPCS LLESY FETNSECSKP GVIFLTKKGR RFCANPSDKQ VQVCMRMLKL DTRIKTRKN
• Sequence Length: 137

• Endotoxin Level: < 0.1 ng per ug of MIP-3
• Biological Activity: Determined by its ability to chemoattract human T cell population using a concentration of 10-50 ng/ml.

Related Product Information for MIP-3 (CCL23) active protein

MIP-3 is a CC chemokine that signals through the CCR1 receptor. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. Recombinant human MIP-3 is an 11.3 kDa protein containing 99 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Product Categories/Family for MIP-3 (CCL23) active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 22538806
• NCBI GeneID: 6368
• NCBI Accession #: NP_005055.2
• NCBI GenBank Nucleotide #: NM_005064.4
• UniProt Accession #: P55773; O00174; O75950; Q52LD4; B7ZKQ3
• Molecular Weight: 11.3 kDa
• NCBI Official Full Name: C-C motif chemokine 23 isoform CKbeta8-1
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 23
• NCBI Official Symbol: CCL23
• NCBI Official Synonym Symbols: CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8
• NCBI Protein Information: C-C motif chemokine 23; C6 beta-chemokine; macrophage inflammatory protein 3; myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23
• UniProt Protein Name: C-C motif chemokine 23
• UniProt Gene Name: CCL23
• UniProt Synonym Gene Names: MIP3; MPIF1; SCYA23; CKB-8; MIP-3; MPIF-1
• UniProt Entry Name: CCL23_HUMAN

NCBI Description

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Uniprot Description

Function: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. Ref.9

Subcellular location: Secreted.

Tissue specificity: High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. Ref.9

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.