Thymosin-beta4 Active Protein | TMSB4X active protein

Human Thymosin-beta4

Cat. Num. AAA691788

• Gene Names: TMSB4X; FX; TB4X; PTMB4; TMSB4
• Reactivity: Human
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Synonyms: Thymosin-beta4; Human Thymosin-beta4; Hematopietic system regulatory peptide; Seraspenide; TMSB4X; TMSB4; TMSB4X active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 95% by SDS-PAGE & HPLC analyses
• Form/Format: Lyophilized
• Sequence: RMSDKPDMAE IEKFDKSKLK KTETQEKNPL PSKETIEQEK QAGES
• Sequence Length: 44

• Biological Activity: Pretreatment of primary lung fibroblasts with recombinant Thymosin-beta4, using a concentration of 0.5 - 10 ug/ml, produces a protective effect against hydrogen peroxide induced cell death.

Related Product Information for TMSB4X active protein

Thymosin-beta4 is a small, actin-sequestering protein belonging to the thymosin-beta family that is found at high concentrations within the spleen, thymus, and peritoneal macrophages, where it is most notably responsible for the organization of cytoskeletal structure. In mammalian tissues, this protein acts as a modulator for the polymerization/depolymerization of actin through the formation of a 1:1 complex with the monomer G (globular)-actin, and inhibits actin's polymerization to form F (filamentous) actin, which together with other proteins binds microfilaments to construct the cytoskeleton. Commonly found at significant quantities within the brain, lungs, liver, kidneys, testes, and heart, Thymosin-beta4 has also been shown to be synthesized by cells unrelated to the reticuloendothelial system, such as myoblasts and fibroblasts, and expressed at irregular levels by several hemopoietic cell lines, malignant lymphoid cells and myeloma cells. In addition to regulating actin polymerization, research has also found Thymosin-beta4 to stimulate the secretion of hypothalamic luteinizing hormone-releasing hormone and luteinizing hormone, inhibit the migration of peritoneal macrophages, induce phenotypic changes in T cell lines during early host defense mechanisms, and inhibit the progression of hematopoietic pluripotent stem cells into the s-phase. Recombinant Human Thymosin-beta4 is a 5.2 kDa glycoprotein containing 45 amino acid residues.

Product Categories/Family for TMSB4X active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 11056061
• NCBI GeneID: 7114
• NCBI Accession #: NP_066932.1
• NCBI GenBank Nucleotide #: NM_021109.3
• UniProt Accession #: P62328; P01253; P01254; Q546P5; Q63576; Q9UE55
• Molecular Weight: 5,053 Da
• NCBI Official Full Name: thymosin beta-4
• NCBI Official Synonym Full Names: thymosin beta 4, X-linked
• NCBI Official Symbol: TMSB4X
• NCBI Official Synonym Symbols: FX; TB4X; PTMB4; TMSB4
• NCBI Protein Information: thymosin beta-4; t beta-4; prothymosin beta-4; thymosin, beta 4, X chromosome
• UniProt Protein Name: Thymosin beta-4
• Protein Family: Thymosin
• UniProt Gene Name: TMSB4X
• UniProt Synonym Gene Names: TB4X; THYB4; TMSB4; T beta-4
• UniProt Entry Name: TYB4_HUMAN

NCBI Description

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Plays an important role in the organization of the cytoskeleton

By similarity. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase

By similarity.

Subunit structure: Interacts with SERPINB1

By similarity. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X. Ref.4 Ref.10

Subcellular location: Cytoplasm › cytoskeleton.

Tissue specificity: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. Ref.1

Induction: By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant interferon-lambda. Ref.1 Ref.5

Sequence similarities: Belongs to the thymosin beta family.