PDGF-AA active protein
Mouse PDGF-AA
NCBI and Uniprot Product Information
Uniprot Description
Function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.12
Subunit structure: Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4
By similarity.
Subcellular location: Secreted. Note: Released by platelets upon wounding.
Tissue specificity: Expression primarily localized in papillary regions with presumable expression in tubular cells comprising the loop of Henle. In the renal cortex, a widespread expression seen in the vascular smooth muscle cells and is barely detectable in interstitial cells. Ref.9
Domain: The long form contains a basic insert which acts as a cell retention signal.
Disruption phenotype: Lethal, due to defects in cell proliferation and migration, leading to defects in the development of the embryonic lung, gastrointestinal tract, oligodendrocytes and Leydig cells. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.11
Sequence similarities: Belongs to the PDGF/VEGF growth factor family.
Research Articles on PDGF-AA
Similar Products
Product Notes
The PDGF-AA pdgfa (Catalog #AAA691784) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse PDGF-AA reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGC CNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL EC ACATSNLN PDHREEETGR RRESGKNRKR KRLKPT. It is sometimes possible for the material contained within the vial of "PDGF-AA, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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