IL-13 active protein
Mouse IL-13
Gene Names
Il13; Il-13
Reactivity
Mouse
Purity
> 98% by SDS-PAGE and HPLC analysis
Synonyms
IL-13; Mouse IL-13; Recombinant Murine IL-13; IL-13 active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized
Sequence
MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGF CVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE V AHFITKLLS YTKQLFRHGP F
Sequence Length
131
Endotoxin Level
< 0.1 ng per ug of IL-13
Biological Activity
The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 4.0 ng/ml, corresponding to a specific activity of > 2.5 x 105 units/mg.
Related Product Information for IL-13 active protein
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues.
Product Categories/Family for IL-13 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
12.3 kDa
NCBI Official Full Name
interleukin-13
NCBI Official Synonym Full Names
interleukin 13
NCBI Official Symbol
Il13
NCBI Official Synonym Symbols
Il-13
NCBI Protein Information
interleukin-13; T-cell activation protein P600
UniProt Protein Name
Interleukin-13
UniProt Gene Name
Il13
UniProt Synonym Gene Names
Il-13; IL-13
UniProt Entry Name
IL13_MOUSE
Uniprot Description
Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses
By similarity.
Subunit structure: Interacts with IL13RA2
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the IL-4/IL-13 family.
Research Articles on IL-13
Similar Products
Product Notes
The IL-13 il13 (Catalog #AAA691604) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse IL-13 reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGF CVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE V AHFITKLLS YTKQLFRHGP F. It is sometimes possible for the material contained within the vial of "IL-13, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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