Midkine Active Protein | MDK active protein
Human Midkine
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Uniprot Description
Function: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development
By similarity. Ref.2 Ref.11
Subunit structure: Homodimer. Interacts with ALK. Ref.11 Ref.12
Subcellular location: Secreted.
Tissue specificity: Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. Ref.5
Induction: By heparin and retinoic acid. Ref.2 Ref.9
Sequence similarities: Belongs to the pleiotrophin family.
Research Articles on MDK
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Product Notes
The MDK mdk (Catalog #AAA691539) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Midkine reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQ RIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA R YNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD. It is sometimes possible for the material contained within the vial of "Midkine, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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