BD-3 active protein

Human BD-3

Cat. Num. AAA691512

• Gene Names: DEFB103A; BD-3; HBD3; HBP3; DEFB3; HBP-3; hBD-3; DEFB-3; DEFB103
• Reactivity: Human
• Purity: > 98% by SDS-PAGE and HPLC analyses
• Synonyms: BD-3; Human BD-3; Recombinant Human BD-3; BD-3 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE and HPLC analyses
• Form/Format: Lyophilized
• Sequence: GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK
• Sequence Length: 67

• Endotoxin Level: < 0.1 ng per ug of BD-3
• Biological Activity: Exhibits antimicrobial activity against gram-positive bacteria S. aureus and gram-negative P. aeruginosa and E.coli.

Related Product Information for BD-3 active protein

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.

Product Categories/Family for BD-3 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 125656159
• NCBI GeneID: 414325
• NCBI Accession #: NP_001075020.1
• NCBI GenBank Nucleotide #: NM_001081551.2
• UniProt Accession #: P81534; Q8NFG6; Q9NPF6
• Molecular Weight: 5.1 kDa
• NCBI Official Full Name: beta-defensin 103
• NCBI Official Synonym Full Names: defensin, beta 103A
• NCBI Official Symbol: DEFB103A
• NCBI Official Synonym Symbols: BD-3; HBD3; HBP3; DEFB3; HBP-3; hBD-3; DEFB-3; DEFB103
• NCBI Protein Information: beta-defensin 103; beta-defensin 3; defensin, beta 3; defensin, beta 103; defensin-like protein
• UniProt Protein Name: Beta-defensin 103
• UniProt Gene Name: DEFB103A
• UniProt Synonym Gene Names: BD3; DEFB103; DEFB3; BD-3; DEFB-3; HBD3; hBD-3
• UniProt Entry Name: D103A_HUMAN

NCBI Description

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]

Uniprot Description

Function: Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. Ref.1

Subcellular location: Secreted.

Tissue specificity: Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. Ref.1

Induction: By bacterial infection and by IFNG/IFN-gamma. Ref.1

Sequence similarities: Belongs to the beta-defensin family.

Mass spectrometry: Molecular mass is 5154.59 Da from positions 23 - 67. Determined by ESI. Ref.1