IL-9 active protein

Human IL-9

Cat. Num. AAA691501

• Gene Names: IL9; P40; HP40; IL-9
• Reactivity: Human
• Purity: > 98% by SDS-PAGE and HPLC analysis
• Synonyms: IL-9; Human IL-9; Recombinant Human IL-9; IL-9 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE and HPLC analysis
• Form/Format: Lyophilized
• Sequence: MQGCPTLAGI LDINFLINKM QEDPASKCHC SANVTSCLCL GIPSDN CTRP CFSERLSQMT NTTMQTRYPL IFSRVKKSVE VLKNNKCPYF S CEQPCNQTT AGNALTFLKS LLEIFQKEKM RGMRGKI
• Sequence Length: 144

• Endotoxin Level: < 0.1 ng per ug of IL-9
• Biological Activity: The ED50 as determined by the dose-dependent proliferation of human M07e cells was <= 0.2 ng/ml, corresponding to a specific activity of >= 5 x 106 units/mg.

Related Product Information for IL-9 active protein

IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin\'s disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant human IL-9 is a 14.0 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human murine proteins.

Product Categories/Family for IL-9 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 10834980
• NCBI GeneID: 3578
• NCBI Accession #: NP_000581.1
• NCBI GenBank Nucleotide #: NM_000590.1
• UniProt Accession #: P15248
• Molecular Weight: 15.8 kDa
• NCBI Official Full Name: interleukin-9
• NCBI Official Synonym Full Names: interleukin 9
• NCBI Official Symbol: IL9
• NCBI Official Synonym Symbols: P40; HP40; IL-9
• NCBI Protein Information: interleukin-9; cytokine P40; p40 cytokine; T-cell growth factor p40; p40 T-cell and mast cell growth factor; homolog of mouse T cell and mast cell growth factor 40
• UniProt Protein Name: Interleukin-9
• UniProt Gene Name: IL9
• UniProt Synonym Gene Names: IL-9
• UniProt Entry Name: IL9_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Supports IL-2 independent and IL-4 independent growth of helper T-cells.

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-7/IL-9 family.