Hamster Glutamate Cysteine Ligase Catalytic Subunit ELISA Kit | GCLC elisa kit

Hamster Glutamate Cysteine Ligase Catalytic Subunit ELISA Kit

Cat. Num. AAA6723

• Gene Names: GCLC; GCL; GCS; GLCL; GLCLC
• Reactivity: Hamster
• Synonyms: Glutamate Cysteine Ligase Catalytic Subunit; Hamster Glutamate Cysteine Ligase Catalytic Subunit ELISA Kit; GCLC elisa kit

• Reactivity: Hamster

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 308199423
• NCBI GeneID: 2729
• NCBI Accession #: NP_001184044.1
• NCBI GenBank Nucleotide #: NM_001197115.1
• UniProt Accession #: P48506; Q14399
• Molecular Weight: 72,766 Da
• NCBI Official Full Name: glutamate--cysteine ligase catalytic subunit isoform b
• NCBI Official Synonym Full Names: glutamate-cysteine ligase, catalytic subunit
• NCBI Official Symbol: GCLC
• NCBI Official Synonym Symbols: GCL; GCS; GLCL; GLCLC
• NCBI Protein Information: glutamate--cysteine ligase catalytic subunit; gamma-ECS; GCS heavy chain; gamma-glutamylcysteine synthetase
• UniProt Protein Name: Glutamate--cysteine ligase catalytic subunit
• Protein Family: Glutamate--cysteine ligase
• UniProt Gene Name: GCLC
• UniProt Synonym Gene Names: GLCL; GLCLC
• UniProt Entry Name: GSH1_HUMAN

NCBI Description

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

Uniprot Description

GCLC: Defects in GCLC are the cause of hemolytic anemia (HAGGSD). Belongs to the glutamate--cysteine ligase type 3 family.

Protein type: EC 6.3.2.2; Other Amino Acids Metabolism - glutathione; Ligase

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: glutamate-cysteine ligase complex; cytosol

Molecular Function: glutamate binding; protein heterodimerization activity; glutamate-cysteine ligase activity; magnesium ion binding; ADP binding; coenzyme binding; ATP binding

Biological Process: glutamate metabolic process; response to arsenic; response to hormone stimulus; L-ascorbic acid metabolic process; response to nitrosative stress; apoptotic mitochondrial changes; cysteine metabolic process; sulfur amino acid metabolic process; cell redox homeostasis; response to heat; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; xenobiotic metabolic process; glutathione biosynthetic process; negative regulation of protein ubiquitination; response to oxidative stress; negative regulation of neuron apoptosis; regulation of blood vessel size; negative regulation of transcription, DNA-dependent; regulation of mitochondrial depolarization; negative regulation of apoptosis

Disease: Gamma-glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To; Myocardial Infarction, Susceptibility To