Mouse anti-Human IL-21 Monoclonal Antibody | anti-IL21 antibody
Mouse Anti-Human IL-21-BIOT
Interleukin-21 (IL-21) is a four helical bundle type I cytokine1. The mature form of human IL-21 is a 131 amino acid protein.4 IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells and augmentation of antitumor activity of CD8+ T cells.2, 3 Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases. Clone SB134f can be used as a detection antibody for sandwich ELISA.5
Reagents are stable for the period shown on the label if stored as directed.
2) Ettinger, R., et al. (2005). J. Immunol. 175:7867-7879.
3) Kuchen, S., et al. (2007). J. Immunol. 179:5886-5896.
4) Parrish-Novak, J. et al. (2000). Nature. 408:57-63.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells
By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Ref.1 Ref.6
Subcellular location: Secreted Ref.1.
Tissue specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. Ref.1
Sequence similarities: Belongs to the IL-15/IL-21 family.
Sequence caution: The sequence AAG29348.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66258.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66259.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66260.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66261.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH66262.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH69124.1 differs from that shown. Reason: Erroneous initiation. The sequence AAU88182.1 differs from that shown. Reason: Erroneous initiation. The sequence ABG36529.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on IL21
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Product Notes
The IL21 il21 (Catalog #AAA670222) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human IL-21-BIOT reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-21 can be used in a range of immunoassay formats including, but not limited to, ELISA. ELISA: 1.0 - 5.0ug/mL. Researchers should empirically determine the suitability of the IL21 il21 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-21, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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