Testing Data
(Fig-1: Neutralization of binding between SARS-Cov-2 Spike RBD protein and CHO-K1/ACE2 cells by the Recombinant Anti-SARS-CoV-2 Spike RBD antibody (CR3022). CHO-K1/ACE2 stable cells were incubated with various concentrations of RBD antibody (CR3022) in the presence of biotinylated SARS-Cov-2 Spike RBD protein and analyzed through In-Cell ELISA using HRP-Streptavidin for detection.)
Human COVID 19 Spike RBD Coronavirus Monoclonal Antibody | anti-COVID-19 antibody
Recombinant Anti-SARS-CoV-2 Spike RBD antibody (CR3022)
Applications
Functional Assay, ELISA
Purity
Affinity purified
Synonyms
COVID 19 Spike RBD Coronavirus; Monoclonal Antibody; Recombinant Anti-SARS-CoV-2 Spike RBD antibody (CR3022); 2019 Novel Coronavirus; Coronavirus; CoV; COVID-19 virus; HCoV-2; Human Coronavirus 2019; SARS2; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike RBD; Receptor Binding Domain; anti-COVID-19 antibody
Host
Human
Clonality
Monoclonal
Isotype
Human IgG1, kappa
Clone Number
CR3022
Purity/Purification
Affinity purified
Form/Format
Purified; 0.5mg/ml, 100ug in sterile PBS
Applicable Applications for anti-COVID-19 antibody
Functional Assay (FA), ELISA (EIA)
Antibody Type
Recombinant Antibody
Immunogen
Tissue, cells or virus corresponding to Human coronavirus SARS-CoV-2 Spike Glycoprotein S1. The original monoclonal antibody was generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV.
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles.
Testing Data
(Fig-1: Neutralization of binding between SARS-Cov-2 Spike RBD protein and CHO-K1/ACE2 cells by the Recombinant Anti-SARS-CoV-2 Spike RBD antibody (CR3022). CHO-K1/ACE2 stable cells were incubated with various concentrations of RBD antibody (CR3022) in the presence of biotinylated SARS-Cov-2 Spike RBD protein and analyzed through In-Cell ELISA using HRP-Streptavidin for detection.)
Testing Data
(Fig-1: Neutralization of binding between SARS-Cov-2 Spike RBD protein and CHO-K1/ACE2 cells by the Recombinant Anti-SARS-CoV-2 Spike RBD antibody (CR3022). CHO-K1/ACE2 stable cells were incubated with various concentrations of RBD antibody (CR3022) in the presence of biotinylated SARS-Cov-2 Spike RBD protein and analyzed through In-Cell ELISA using HRP-Streptavidin for detection.)
Related Product Information for anti-COVID-19 antibody
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Product Categories/Family for anti-COVID-19 antibody
NCBI and Uniprot Product Information
UniProt Accession #
Similar Products
Product Notes
The COVID-19 (Catalog #AAA669468) is an Antibody produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's COVID 19 Spike RBD Coronavirus can be used in a range of immunoassay formats including, but not limited to, Functional Assay (FA), ELISA (EIA). Researchers should empirically determine the suitability of the COVID-19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COVID 19 Spike RBD Coronavirus, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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