Pancreatic Polypeptide | PPY peptide

Pancreatic Polypeptide (31-36) (human)

Cat. Num. AAA659000

• Gene Names: PPY; PNP
• Reactivity: Human
• Purity: Highly Purified; ~95%. Purified by HPLC.
• Synonyms: Pancreatic Polypeptide; Pancreatic Polypeptide (31-36) (human); PPY peptide

• Host: Synthetic peptide
• Reactivity: Human
• Purity/Purification: Highly Purified; ~95%. Purified by HPLC.
• Form/Format: Supplied as a lyophilized powder.

• Sequence (linear): Leu-Thr-Arg-Pro-Arg-Tyr-NH2
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for PPY peptide

Molecular Biology; MB-Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 119572034
• NCBI GeneID: 5539
• UniProt Accession #: P01298
• Molecular Weight: 10,445 Da
• NCBI Official Full Name: pancreatic polypeptide
• NCBI Official Synonym Full Names: pancreatic polypeptide
• NCBI Official Symbol: PPY
• NCBI Official Synonym Symbols: PNP
• NCBI Protein Information: pancreatic prohormone; PP; pancreatic polypeptide Y; prepro-PP (prepropancreatic polypeptide)
• UniProt Protein Name: Pancreatic prohormone
• Protein Family: Pancreatic hormone
• UniProt Gene Name: PPY
• UniProt Synonym Gene Names: PNP; PP; PH; PI
• UniProt Entry Name: PAHO_HUMAN

NCBI Description

This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.The physiological role for the icosapeptide has not yet been elucidated.

Subcellular location: Secreted.

Pharmaceutical use: Obinepitide is under clinical trial by 7TM Pharma to be used for the treatment of obesity. Obinepitide is derived from pancreatic hormone by having Gln-63.

Sequence similarities: Belongs to the NPY family.