Rabbit anti-Human ZBTB16 Polyclonal Antibody | anti-ZBTB16 antibody

ZBTB16, Phosphorylated (Tyr334) (Zinc Finger And BTB Domain-containing Protein 16, Zinc Finger Protein PLZF, Promyelocytic Leukemia Zinc Finger Protein, Zinc Finger Protein 145, ZBTB16, PLZF, ZNF145) (AP)

Cat. Num. AAA6506575

• Gene Names: ZBTB16; PLZF; ZNF145
• Reactivity: Human
• Applications: ELISA, Dot Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ZBTB16; Polyclonal Antibody; Phosphorylated (Tyr334) (Zinc Finger And BTB Domain-containing Protein 16; Zinc Finger Protein PLZF; Promyelocytic Leukemia Zinc Finger Protein; Zinc Finger Protein 145; PLZF; ZNF145) (AP); anti-ZBTB16 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ZBTB16 when phosphorylated at Tyr334.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-ZBTB16 antibody: ELISA (EIA), Dot Blot (DB)
• Application Notes: ELISA: 1:1,000; Dot Blot: 1:500; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y334 of human ZBTB16, UniProt Accession #Q05516.
• Conjugate: AP
• Antigen Modification: Phosphorylated
• Note: Preservative Free
• Preparation and Storage: May be stored at 4 degree C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Dot Blot (DB)

(Dot Blot analysis of MBS624594 on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug/ml.)

Product Categories/Family for anti-ZBTB16 antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger

References

1. Labbaye, C., Nat. Cell Biol. 10(7), 788-801 (2008). 2. Kang, S.I., Biochem. Biophys. Res. Commun. 369(4), 1209-1214 (2008). 3. Felicetti, F., Cancer Res. 68(8), 2745-2754 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 21359888
• NCBI GeneID: 7704
• NCBI Accession #: NP_005997
• NCBI GenBank Nucleotide #: NM_006006
• UniProt Accession #: Q05516
• Molecular Weight: 74kDa
• NCBI Official Full Name: zinc finger and BTB domain-containing protein 16 isoform 1
• NCBI Official Synonym Full Names: zinc finger and BTB domain containing 16
• NCBI Official Symbol: ZBTB16
• NCBI Official Synonym Symbols: PLZF; ZNF145
• NCBI Protein Information: zinc finger and BTB domain-containing protein 16
• UniProt Protein Name: Zinc finger and BTB domain-containing protein 16
• Protein Family: Zinc finger and BTB domain-containing protein
• UniProt Gene Name: ZBTB16
• UniProt Synonym Gene Names: PLZF; ZNF145
• UniProt Entry Name: ZBT16_HUMAN

NCBI Description

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.