Fibroblast Growth Factor 5 Active Protein | FGF5 active protein

Fibroblast Growth Factor 5, Recombinant, Human (FGF5)

Cat. Num. AAA650544

• Gene Names: FGF5; HBGF-5; Smag-82
• Purity: Molecular Biology Grade; 98% by SDS-PAGE and HPLC.
• Synonyms: Fibroblast Growth Factor 5; Recombinant; Human (FGF5); FGF5 active protein

• Host: E Coli
• Purity/Purification: Molecular Biology Grade; 98% by SDS-PAGE and HPLC.
• Form/Format: Supplied as a lyophilized powder from PBS, pH 7.2.

• Biological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is 0.5ng/ml, corresponding to a speci c activity of 2x10e6u/mg.
• Country of Origin: USA
• Endotoxin Level: 0.1ng/ug (1EU/ug).
• Reconstitution: Reconstitute in PBS to a concentration of 0.1-1mg/ml.
• Preparation and Storage: Lyophilized powder may be stored at RT/4 degree C for short-term only. Reconstitute to nominal volume by adding sterile PBS, aliquot and store at -20 degree C. Reconstituted product is stable for 12-12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for FGF5 active protein

Fibroblast Growth Factor-5 is a heparin binding growth factor that stimulates the proliferation and activation of cells that express FGF receptors. Recombinant Human FGF-5 is a 27.5kD protein containing 252 amino residues.

Product Categories/Family for FGF5 active protein

Growth Factors; Cytokines; Growth Factors-FGF

NCBI and Uniprot Product Information

• NCBI GI #: 182545
• NCBI GeneID: 2250
• UniProt Accession #: P12034; O75846; Q3Y8M3; B2R554; Q6A549; Q8NBG6; Q8NF90
• Molecular Weight: 29,551 Da
• NCBI Official Full Name: fibroblast growth factor 5
• NCBI Official Synonym Full Names: fibroblast growth factor 5
• NCBI Official Symbol: FGF5
• NCBI Official Synonym Symbols: HBGF-5; Smag-82
• NCBI Protein Information: fibroblast growth factor 5; OTTHUMP00000160795; OTTHUMP00000160796; heparin-binding growth factor 5
• UniProt Protein Name: Fibroblast growth factor 5
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF5
• UniProt Entry Name: FGF5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Uniprot Description

Function: Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase

Subcellular location: Secreted

Potential.

Tissue specificity: Expressed in neonatal brain.

Developmental stage: Can transform NIH 3T3 cells.

Sequence similarities: Belongs to the heparin-binding growth factors family.

Sequence caution: The sequence AAB60698.1 differs from that shown. Reason: Erroneous gene model prediction.