Rabbit anti-Human, Mouse SULT1A1 Polyclonal Antibody | anti-SULT1A1 antibody

SULT1A1, ID (Sulfotransferase 1A1, ST1A1,Aryl Sulfotransferase 1, Phenol Sulfotransferase 1, Phenol-sulfating Phenol Sulfotransferase 1, P-PST 1, Thermostable Phenol Sulfotransferase, Ts-PST, HAST1/HAST2, ST1A3, STP, STP1, OK/SW-cl.88) (AP)

Cat. Num. AAA6501465

• Gene Names: SULT1A1; PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: SULT1A1; Polyclonal Antibody; ID (Sulfotransferase 1A1; ST1A1; Aryl Sulfotransferase 1; Phenol Sulfotransferase 1; Phenol-sulfating Phenol Sulfotransferase 1; P-PST 1; Thermostable Phenol Sulfotransferase; Ts-PST; HAST1/HAST2; ST1A3; STP; STP1; OK/SW-cl.88) (AP); anti-SULT1A1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SULT1A1. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-SULT1A1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-1:500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the central region of human SULT1A1 (KLH).
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: May be stored at 4 degree C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(The anti-SULT1A1 Pab is used in Western blot to detect SULT1A1 in mouse kidney tissue lysate.)

Western Blot (WB)

(Western blot analysis of SULT1A1 (arrow) using rabbit polyclonal SULT1A1 Antibody (Y143). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SULT1A1 gene.)

Product Categories/Family for anti-SULT1A1 antibody

Antibodies; Enzymes; Sulfotransferase

References

1. Carcinogenesis 25(5), 773-778 (2004). 2. J. Biol. Chem. 279(18), 18799-18805 (2004). 3. Cancer Lett. 202(1), 61-69 (2003). 4. J. Biol. Chem. 278(9), 7655-7662 (2003). 5. Int. J. Cancer 103(1), 101-104 (2003). 6.Chem. Biol. Interact. 129(1-2), 141-170 (2000).

NCBI and Uniprot Product Information

• NCBI GI #: 313104286
• NCBI GeneID: 6817
• UniProt Accession #: P50225; Q2NL71; Q86U58; Q92818; Q9BVU6; Q9UGG7
• Molecular Weight: Calculated MW: 25kDa/34kDa; Observe MW: 33kDa
• NCBI Official Full Name: Sulfotransferase 1A1
• NCBI Official Synonym Full Names: sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
• NCBI Official Symbol: SULT1A1
• NCBI Official Synonym Symbols: PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2
• NCBI Protein Information: sulfotransferase 1A1; ts-PST; P-PST 1; aryl sulfotransferase 1; thermostable phenol sulfotransferase1; phenol-sulfating phenol sulfotransferase 1
• UniProt Protein Name: Sulfotransferase 1A1
• Protein Family: Sulfotransferase
• UniProt Gene Name: SULT1A1
• UniProt Synonym Gene Names: STP; STP1; ST1A1; P-PST 1; Ts-PST
• UniProt Entry Name: ST1A1_HUMAN

NCBI Description

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SULT1A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.8.2.1; Energy Metabolism - sulfur; Transferase

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: cytosol

Molecular Function: sulfotransferase activity; steroid sulfotransferase activity; flavonol 3-sulfotransferase activity; aryl sulfotransferase activity

Biological Process: estrogen metabolic process; flavonoid metabolic process; xenobiotic metabolic process; sulfation; catecholamine metabolic process; amine metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process