Immunohistochemistry (IHC)
(Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with ORAI2 antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Rabbit anti-Human ORAI2 Polyclonal Antibody | anti-ORAI2 antibody
ORAI2, CT (Protein Orai-2, CAP-binding Protein Complex-interacting Protein 2, Transmembrane Protein 142B, C7orf19, CBCIP2, TMEM142B, PP1729)
Gene Names
ORAI2; CBCIP2; C7orf19; MEM142B; TMEM142B
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
ORAI2; Polyclonal Antibody; CT (Protein Orai-2; CAP-binding Protein Complex-interacting Protein 2; Transmembrane Protein 142B; C7orf19; CBCIP2; TMEM142B; PP1729); Anti -ORAI2; anti-ORAI2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human ORAI2. Species sequence homology: Mouse.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Applicable Applications for anti-ORAI2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Dilution: Western Blot: 2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Immunogen
Synthetic peptide corresponding to 15aa from human ORAI2 at C-terminal (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunohistochemistry (IHC)
(Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with ORAI2 antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Immunohistochemistry (IHC)
(Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with ORAI2 antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Immunohistochemistry (IHC)
(Human Placenta (formalin-fixed, paraffin-embedded) stained with ORAI2 antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Immunohistochemistry (IHC)
(Human Placenta (formalin-fixed, paraffin-embedded) stained with ORAI2 antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Related Product Information for anti-ORAI2 antibody
ORAI2, also known as Transmembrane protein 142B (TMEM142B), is a 28.6kD multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI2 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI2, like ORAI1, functions as a highly selective Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor.
Product Categories/Family for anti-ORAI2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
28,570 Da
NCBI Official Full Name
ORAI2 protein
NCBI Official Synonym Full Names
ORAI calcium release-activated calcium modulator 2
NCBI Official Symbol
ORAI2
NCBI Official Synonym Symbols
CBCIP2; C7orf19; MEM142B; TMEM142B
NCBI Protein Information
protein orai-2; H_NH0514P08.8; putative protein ORAI2-2; transmembrane protein 142B; CAP-binding protein complex interacting protein 2; CAP-binding protein complex-interacting protein 2
UniProt Protein Name
Protein orai-2
Protein Family
UniProt Gene Name
ORAI2
UniProt Synonym Gene Names
C7orf19; CBCIP2; TMEM142B
UniProt Entry Name
ORAI2_HUMAN
Uniprot Description
Function: Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1. Ref.6 Ref.8
Subunit structure: Interacts with EFCAB4B/CRACR2A. Ref.9
Subcellular location: Membrane; Multi-pass membrane protein
By similarity.
Sequence similarities: Belongs to the Orai family.
Sequence caution: The sequence AAG23755.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.The sequence AAP22352.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAG33568.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.
Research Articles on ORAI2
Similar Products
Product Notes
The ORAI2 orai2 (Catalog #AAA649687) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ORAI2, CT (Protein Orai-2, CAP-binding Protein Complex-interacting Protein 2, Transmembrane Protein 142B, C7orf19, CBCIP2, TMEM142B, PP1729) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ORAI2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Dilution: Western Blot: 2ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml. Researchers should empirically determine the suitability of the ORAI2 orai2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ORAI2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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