Rabbit anti-Human Follicle Stimulating Hormone Receptor Polyclonal Antibody | anti-FSHR antibody

Follicle Stimulating Hormone Receptor, ID (FSHr, FSH-R, Follitropin Receptor, LGR1)

Cat. Num. AAA649574

• Gene Names: FSHR; LGR1; ODG1; FSHRO
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Follicle Stimulating Hormone Receptor; Polyclonal Antibody; ID (FSHr; FSH-R; Follitropin Receptor; LGR1); Anti -Follicle Stimulating Hormone Receptor; anti-FSHR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes endogenous levels of total human FSHR.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

• Applicable Applications for anti-FSHR antibody: ELISA (EL/EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Suitable for use in ELISA, Immunofluorescence and Immunohistochemistry.; Dilution: ELISA: 1:1000; Immunofluorescence: 1:100-1:500; Immunohistochemistry (FFPE): 10ug/ml
• Immunogen: Synthetic peptide corresponding to human FSHR.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(MBS649574 Immunohistochemistry staining of human ovary using formalin fixed parffin embedded tissue after heat induced antigen retrieval. (10ug/ml))

Immunofluorescence (IF)

(Immunofluorescence analysis of MCF7 cells, using MBS649574. The picture on the right is treated with the synthesized peptide.)

Related Product Information for anti-FSHR antibody

FSHR, a Glycoprotein Hormone Receptor, is required for normal ovarian development and follicle maturation in females. When activated, it stimulates ovarian follicular growth and production of estrogens, initiating a normal menstrual cycle. In males, FSHR is required for the initiation of spermatogenesis and normal sperm production. Two isoforms are produced by alternative splicing.

Product Categories/Family for anti-FSHR antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 300073
• NCBI GeneID: 2492
• UniProt Accession #: P23945; Q05AH0; Q16225; Q4QRJ3; Q4ZFZ2; Q53RW2; A8K947
• Molecular Weight: 78,265 Da
• NCBI Official Full Name: follicle stimulating hormone receptor
• NCBI Official Synonym Full Names: follicle stimulating hormone receptor
• NCBI Official Symbol: FSHR
• NCBI Official Synonym Symbols: LGR1; ODG1; FSHRO
• NCBI Protein Information: follicle-stimulating hormone receptor; FSH receptor; follitropin receptor
• UniProt Protein Name: Follicle-stimulating hormone receptor
• Protein Family: Follicle-stimulating hormone receptor
• UniProt Gene Name: FSHR
• UniProt Synonym Gene Names: LGR1; FSH-R
• UniProt Entry Name: FSHR_HUMAN

NCBI Description

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Description

Function: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subunit structure: Interacts with ARRB2

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Tissue specificity: Sertoli cells and ovarian granulosa cells.

Post-translational modification: N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone

By similarity. Ref.12

Involvement in disease: Ovarian dysgenesis 1 (ODG1) [MIM:233300]: An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Ref.16 Ref.17 Ref.18 Ref.22 Ref.23 Ref.24Ovarian hyperstimulation syndrome (OHSS) [MIM:608115]: Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.25 Ref.26 Ref.27 Ref.28 Ref.29

Sequence similarities: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.Contains 9 LRR (leucine-rich) repeats.Contains 1 LRRNT domain.