Rabbit anti-Human GRPEL1 Polyclonal Antibody | anti-GRPEL1 antibody

GRPEL1, ID (GRPEL1, GREPEL1, GrpE protein homolog 1, mitochondrial, HMGE, Mt-GrpE#1)

Cat. Num. AAA648755

• Gene Names: GRPEL1; HMGE
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: GRPEL1; Polyclonal Antibody; ID (GRPEL1; GREPEL1; GrpE protein homolog 1; mitochondrial; HMGE; Mt-GrpE#1); Anti -GRPEL1; anti-GRPEL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-GRPEL1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: GRPEL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-142 amino acids from the Central region of human GRPEL1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(GRPEL1 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the GRPEL1 antibody detected the GRPEL1 protein (arrow).)

Related Product Information for anti-GRPEL1 antibody

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.

Product Categories/Family for anti-GRPEL1 antibody

Antibodies; Abs to Mitochondrial Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 24308295
• NCBI GeneID: 80273
• NCBI Accession #: NP_079472.1
• NCBI GenBank Nucleotide #: NM_025196.2
• UniProt Accession #: Q9HAV7; Q549M6; B2R783
• Molecular Weight: 24,279 Da
• NCBI Official Full Name: grpE protein homolog 1, mitochondrial
• NCBI Official Synonym Full Names: GrpE-like 1, mitochondrial (E. coli)
• NCBI Official Symbol: GRPEL1
• NCBI Official Synonym Symbols: HMGE
• NCBI Protein Information: grpE protein homolog 1, mitochondrial; mt-GrpE#1; GrpE-like protein cochaperone
• UniProt Protein Name: GrpE protein homolog 1, mitochondrial
• Protein Family: GrpE protein
• UniProt Gene Name: GRPEL1
• UniProt Synonym Gene Names: GREPEL1
• UniProt Entry Name: GRPE1_HUMAN

Uniprot Description

Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.

Subunit structure: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19

By similarity. Binds to HSP70, HSC70 and HSJ1B.

Subcellular location: Mitochondrion matrix.

Sequence similarities: Belongs to the GrpE family.