Rabbit anti-Human, Mouse FIGN Polyclonal Antibody | anti-FIGN antibody

FIGN, CT (FIGN, Fidgetin)

Cat. Num. AAA647918

• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: FIGN; Polyclonal Antibody; CT (FIGN; Fidgetin); Anti -FIGN; anti-FIGN antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human, mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-FIGN antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: FIGN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-643 amino acids from the C-terminal region of human FIGN.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(FIGN Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the FIGN antibody detected the FIGN protein (arrow).)

Related Product Information for anti-FIGN antibody

Fidgetin is a member of the 'meiotic' or subfamily-7 group of ATPases associated with diverse cellular activities (AAA proteins). Fidgetin can interact with itself and this interaction can be abolished by truncating either the N- or C-terminus of the protein. AAA proteins are molecular chaperones that facilitate membrane fusion, proteolysis, peroxisome biogenesis, endosome sorting and meiotic spindle formation.

Product Categories/Family for anti-FIGN antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 64084766
• NCBI GeneID: 55137
• NCBI Accession #: NP_060556.2
• NCBI GenBank Nucleotide #: NM_018086.2
• UniProt Accession #: Q5HY92; Q9H6M5; Q9NVZ9; B3KWM0
• Molecular Weight: 82,146 Da
• NCBI Official Full Name: fidgetin
• NCBI Official Synonym Full Names: fidgetin
• NCBI Official Symbol: FIGN
• NCBI Protein Information: fidgetin
• UniProt Protein Name: Fidgetin
• Protein Family: Fidgetin
• UniProt Gene Name: FIGN
• UniProt Entry Name: FIGN_HUMAN

Uniprot Description

Function: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Ref.4

Subunit structure: Interacts with AKAP8 (via C-terminus)

By similarity.

Subcellular location: Nucleus matrix

By similarity. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Note: Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase. Ref.4

Sequence similarities: Belongs to the AAA ATPase family.

Sequence caution: The sequence AAX81992.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA91590.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAA91590.1 differs from that shown. Reason: Frameshift at position 71. The sequence BAB15231.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.