Immunohistochemistry (IHC)
(Immunohistochemistry Analysis: Positive and background staining patterns on formalin-fixed, paraffin-embedded human ductal carcinoma. Tissue pretreated with citrate pH 6.0 using antigen retrieval techniques. Stained using MBS621147 diluted to 1:300 and detected using HRP/DAB. Immunoreactivity is seen in nucleus and cytoplasm.)
Rabbit anti-Human, Rat ASPM Polyclonal Antibody | anti-ASPM antibody
ASPM (ASP (Abnormal Spindle)-like Microcephaly Associated, Microcephaly, Primary Autosomal Recessive 5, HGNC:19048, FLJ10517, FLJ10549, MCPH5) (APC)
ELISA: Tested in direct ELISA against the ASPM immunogen.
Applications are based on unconjugated antibody.
Immunohistochemistry (IHC)
(Immunohistochemistry Analysis: Positive and background staining patterns on formalin-fixed, paraffin-embedded human ductal carcinoma. Tissue pretreated with citrate pH 6.0 using antigen retrieval techniques. Stained using MBS621147 diluted to 1:300 and detected using HRP/DAB. Immunoreactivity is seen in nucleus and cytoplasm.)
Immunohistochemistry (IHC)
(Immunohistochemistry Analysis: Positive and background staining patterns on formalin-fixed, paraffin-embedded human ductal carcinoma. Tissue pretreated with citrate pH 6.0 using antigen retrieval techniques. Stained using MBS621147 diluted to 1:300 and detected using HRP/DAB. Immunoreactivity is seen in nucleus and cytoplasm.)
NCBI and Uniprot Product Information
Uniprot Description
ASPM: Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis. Defects in ASPM are the cause of microcephaly primary type 5 (MCPH5); also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: microtubule; cytoplasm; midbody; nucleus
Molecular Function: calmodulin binding
Biological Process: oogenesis; positive regulation of neuroblast proliferation; mitosis; developmental growth; maintenance of centrosome localization; negative regulation of neuron differentiation; negative regulation of asymmetric cell division; male gonad development; neuron migration; spermatogenesis; cerebral cortex development; forebrain neuroblast division
Disease: Microcephaly 5, Primary, Autosomal Recessive
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Product Notes
The ASPM aspm (Catalog #AAA6464298) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ASPM (ASP (Abnormal Spindle)-like Microcephaly Associated, Microcephaly, Primary Autosomal Recessive 5, HGNC:19048, FLJ10517, FLJ10549, MCPH5) (APC) reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ASPM can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, ELISA (EIA). IHC-P: 1:300. Positive and background staining patterns on formalin fixed, paraffin embedded human ductal carcinoma. Tissue pretreated with citrate pH 6.0 using antigen retrieval techniques. Detected using HRP/DAB. Immunoreactivity is seen in nucleus and cytoplasm. ELISA: Tested in direct ELISA against the ASPM immunogen. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the ASPM aspm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASPM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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