Western Blot (WB)
(Western Blot detection against Immunogen (69.23kD).)
Mouse anti-Human ANO10 Monoclonal Antibody | anti-ANO10 antibody
ANO10 (Anoctamin-10, Transmembrane Protein 16K, TMEM16K, FLJ10375, Anoctamin 10, MGC47890)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot detection against Immunogen (69.23kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (69.23kD).)
NCBI and Uniprot Product Information
NCBI Description
The transmembrane protein encoded by this gene is a member of a family of calcium-activated chloride channels. Defects in this gene may be a cause of autosomal recessive spinocerebellar ataxia-10. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Uniprot Description
ANO10: May act as a calcium-activated chloride channel. Defects in ANO10 are the cause of spinocerebellar ataxia autosomal recessive type 10 (SCAR10). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. Belongs to the anoctamin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ion channel; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p22.1
Cellular Component: membrane; integral to membrane; plasma membrane; intracellular
Molecular Function: intracellular calcium activated chloride channel activity; calcium activated cation channel activity
Biological Process: chloride transport; transmembrane transport; cation transport
Disease: Spinocerebellar Ataxia, Autosomal Recessive 10
Research Articles on ANO10
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Product Notes
The ANO10 ano10 (Catalog #AAA644113) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ANO10 (Anoctamin-10, Transmembrane Protein 16K, TMEM16K, FLJ10375, Anoctamin 10, MGC47890) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ANO10 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the ANO10 ano10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MLLGAEAVGL VKECNDNTMR AFTYRTRQNF KGFDDNNDDF LTMAECQFII KHELENLRAK DEKMIPGYPQ AKLYPGKSLL RRLLTSGIVI QVFPLHDSEA LKKLEDTWYT RFALKYQPIE NHRLESAYQN HLILKVLVFN FLNCFASLFY IAFVLKDMKL LRQSLATLLI TSQILNQIME SFLPYWLQRK HGVRVKRKVQ ALKADIDATL YEQVILEKEM GTYLGTFDDY LELFLQFGYV SLFSCVYPLA AAFAVLNNFT EVNSDALKMC RVFKRPFSEP SANIGVWQLA FEMMSVISVV TNCALIGMSP QVNAAFPESK ADLILIVVAV EHALLALKFI LAFAIPDKPR HIQMKLARLE FESLEALKQQ QMKLVTENLK EEPMESGKEK AT. It is sometimes possible for the material contained within the vial of "ANO10, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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