Rabbit anti-Human, Mouse PPP1R10 Polyclonal Antibody | anti-PPP1R10 antibody

PPP1R10 (Protein Phosphatase 1 Regulatory Subunit 10, p99, FB19, R111, CAT53, PNUTS, PP1R10) (Biotin)

Cat. Num. AAA6432570

• Gene Names: PPP1R10; p99; FB19; R111; CAT53; PNUTS; PP1R10
• Reactivity: Human, Mouse
• Applications: Immunoprecipitation, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: PPP1R10; Polyclonal Antibody; PPP1R10 (Protein Phosphatase 1 Regulatory Subunit 10; p99; FB19; R111; CAT53; PNUTS; PP1R10) (Biotin); anti-PPP1R10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes PPP1R10. Species Crossreactivity: human, mouse
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-PPP1R10 antibody: Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: IP: 1:20-1:50; WB: 1:500-1:1000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to human PPP1R10.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using PPP1R10 antibody.)

Product Categories/Family for anti-PPP1R10 antibody

Antibodies; Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 25777671
• NCBI GeneID: 5514
• NCBI Accession #: NP_002705.2
• NCBI GenBank Nucleotide #: NM_002714.3
• UniProt Accession #: Q96QC0; O00405
• Molecular Weight: 99,058 Da
• NCBI Official Full Name: serine/threonine-protein phosphatase 1 regulatory subunit 10
• NCBI Official Synonym Full Names: protein phosphatase 1, regulatory subunit 10
• NCBI Official Symbol: PPP1R10
• NCBI Official Synonym Symbols: p99; FB19; R111; CAT53; PNUTS; PP1R10
• NCBI Protein Information: serine/threonine-protein phosphatase 1 regulatory subunit 10; HLA-C associated transcript 53; PP1-binding protein of 114 kDa; phosphatase 1 nuclear targeting subunit; MHC class I region proline-rich protein CAT53; protein phosphatase 1, regulatory (inhibi
• UniProt Protein Name: Serine/threonine-protein phosphatase 1 regulatory subunit 10
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: PPP1R10
• UniProt Synonym Gene Names: CAT53; FB19; PNUTS
• UniProt Entry Name: PP1RA_HUMAN

NCBI Description

This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

PNUTS: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

Protein type: Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleoplasm; chromatin; nucleus

Molecular Function: DNA binding; metal ion binding; protein phosphatase inhibitor activity

Biological Process: transcription, DNA-dependent; protein import into nucleus; negative regulation of catalytic activity