Goat anti-Human, Mouse FOXI1 Polyclonal Antibody | anti-FOXI1 antibody

FOXI1 (Forkhead Box Protein I1, Forkhead-related Protein FKHL10, Forkhead-related Transcription Factor 6, FREAC-6, Hepatocyte Nuclear Factor 3 Forkhead Homolog 3, HFH-3, HNF-3/Fork-head Homolog 3, FKHL10, FREAC6)

Cat. Num. AAA643076

• Gene Names: FOXI1; HFH3; FKH10; HFH-3; FKHL10; FREAC6; FREAC-6
• Reactivity: Human, Mouse
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: FOXI1; Polyclonal Antibody; FOXI1 (Forkhead Box Protein I1; Forkhead-related Protein FKHL10; Forkhead-related Transcription Factor 6; FREAC-6; Hepatocyte Nuclear Factor 3 Forkhead Homolog 3; HFH-3; HNF-3/Fork-head Homolog 3; FKHL10; FREAC6); Anti -FOXI1 (Forkhead Box Protein I1; anti-FOXI1 antibody

• Host: Goat
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Recognizes mouse FOXI1. Species sequence homology: Human.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

• Applicable Applications for anti-FOXI1 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:32,000
• Immunogen: Synthetic peptide corresponding to C-TSGVLYPREGTEV, from mouse FOXI1, at C-terminal (NP_036320.2, NP_658982.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-FOXI1 antibody

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-FOXI1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 21618329
• NCBI GeneID: 2299
• NCBI Accession #: NP_658982.1
• NCBI GenBank Nucleotide #: NM_144769.2
• UniProt Accession #: Q12951; Q14518; Q66SR7; Q8N6L8
• Molecular Weight: 40,973 Da
• NCBI Official Full Name: forkhead box protein I1 isoform b
• NCBI Official Synonym Full Names: forkhead box I1
• NCBI Official Symbol: FOXI1
• NCBI Official Synonym Symbols: HFH3; FKH10; HFH-3; FKHL10; FREAC6; FREAC-6
• NCBI Protein Information: forkhead box protein I1; forkhead-like 10; HNF-3/fork-head homolog 3; HNF-3/fork-head homolog-3; forkhead-related activator 6; forkhead-related protein FKHL10; forkhead-related transcription factor 6; hepatocyte nuclear factor 3 forkhead homolog 3
• UniProt Protein Name: Forkhead box protein I1
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXI1
• UniProt Synonym Gene Names: FKHL10; FREAC6; FREAC-6; HFH-3
• UniProt Entry Name: FOXI1_HUMAN

NCBI Description

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FOXI1: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; DNA bending activity; transcription factor activity

Biological Process: embryonic development; inner ear morphogenesis; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Disease: Pendred Syndrome; Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct