Rabbit anti-Mouse FBXO18 Polyclonal Antibody | anti-FBXO18 antibody

FBXO18, CT (FBXO18, FBH1, FBX18, F-box only protein 18, F-box DNA helicase 1)

Cat. Num. AAA641596

• Gene Names: FBXO18; FBH1; Fbx18
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: FBXO18; Polyclonal Antibody; CT (FBXO18; FBH1; FBX18; F-box only protein 18; F-box DNA helicase 1); Anti -FBXO18; anti-FBXO18 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-FBXO18 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: FBXO18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 748-777 amino acids from the C-terminal region of human FBXO18.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(FBXO18 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the FBXO18 antibody detected the FBXO18 protein (arrow).)

Related Product Information for anti-FBXO18 antibody

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Product Categories/Family for anti-FBXO18 antibody

Antibodies; Abs to Ubiquitin Ligases

NCBI and Uniprot Product Information

• NCBI GI #: 386268046
• NCBI GeneID: 84893
• NCBI Accession #: NP_001245382.1
• NCBI GenBank Nucleotide #: NM_001258453.1
• UniProt Accession #: Q8NFZ0; Q5JVB0; Q5JVB1; Q7Z4Q6; Q7Z4R0; Q8N1P5; Q8N586; Q96E82; Q96K67; Q96SW7; Q9UFB2
• Molecular Weight: 117,686 Da
• NCBI Official Full Name: F-box only protein 18 isoform 4
• NCBI Official Synonym Full Names: F-box protein, helicase, 18
• NCBI Official Symbol: FBXO18
• NCBI Official Synonym Symbols: FBH1; Fbx18
• NCBI Protein Information: F-box only protein 18; F-box DNA helicase 1; F-box only protein, helicase, 18
• UniProt Protein Name: F-box only protein 18
• Protein Family: F-box DNA helicase
• UniProt Gene Name: FBXO18
• UniProt Synonym Gene Names: FBH1; FBX18
• UniProt Entry Name: FBX18_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FBXO18: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. Belongs to the helicase family. UvrD subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: nucleus

Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATP binding

Biological Process: positive regulation of protein amino acid phosphorylation; DNA catabolic process, endonucleolytic; DNA duplex unwinding