Rabbit ELOVL4 Polyclonal Antibody | anti-ELOVL4 antibody

ELOVL4 (Elongation of Very Long Chain Fatty Acids Protein 4, ADMD, CT118, ISQMR, STGD2, STGD3) (Biotin)

Cat. Num. AAA6415795

• Gene Names: ELOVL4; ADMD; CT118; ISQMR; STGD2; STGD3
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: ELOVL4; Polyclonal Antibody; ELOVL4 (Elongation of Very Long Chain Fatty Acids Protein 4; ADMD; CT118; ISQMR; STGD2; STGD3) (Biotin); anti-ELOVL4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes ELOVL4. Species Crossreactivity: human, mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-ELOVL4 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to human ELOVL4.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-ELOVL4 antibody

Antibodies; Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 12232379
• NCBI GeneID: 6785
• NCBI Accession #: NP_073563.1
• NCBI GenBank Nucleotide #: NM_022726.3
• UniProt Accession #: Q9GZR5; Q5TCS2; Q86YJ1; Q9H139; B2R6B5
• Molecular Weight: 36,829 Da
• NCBI Official Full Name: elongation of very long chain fatty acids protein 4
• NCBI Official Synonym Full Names: ELOVL fatty acid elongase 4
• NCBI Official Symbol: ELOVL4
• NCBI Official Synonym Symbols: ADMD; CT118; ISQMR; STGD2; STGD3
• NCBI Protein Information: elongation of very long chain fatty acids protein 4; ELOVL FA elongase 4; cancer/testis antigen 118; 3-keto acyl-CoA synthase ELOVL4; Stargardt disease 3 (autosomal dominant); very-long-chain 3-oxoacyl-CoA synthase 4; elongation of very long chain fatty a
• UniProt Protein Name: Elongation of very long chain fatty acids protein 4
• Protein Family: Elongation of very long chain fatty acids protein
• UniProt Gene Name: ELOVL4
• UniProt Synonym Gene Names: ELOVL FA elongase 4
• UniProt Entry Name: ELOV4_HUMAN

NCBI Description

This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008]

Uniprot Description

ELOVL4: Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development. Defects in ELOVL4 are the cause of Stargardt disease type 3 (STGD3). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant. Defects in ELOVL4 are the cause of ichthyosis, spastic quadriplegia, and mental retardation (ISQMR). A severe autosomal recessive disorder characterized by ichthyosis apparent from birth, profound psychomotor retardation with essentially no development, spastic quadriplegia, and seizures. Belongs to the ELO family.

Protein type: Cancer Testis Antigen (CTA); Endoplasmic reticulum; Membrane protein, multi-pass; EC 2.3.1.199; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q14

Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane

Molecular Function: transferase activity; protein binding; G-protein coupled photoreceptor activity

Biological Process: very-long-chain fatty acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid elongation, saturated fatty acid; fatty acid biosynthetic process; detection of visible light

Disease: Spinocerebellar Ataxia 34